Minichromosome Maintenance Deficient 10 (MCM10) (Middle Region) Peptide
MCM10
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MCM10 products
- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM10 antibody (Catalog #: ARP36656_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
- Background
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This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Alias Symbols: CNA43, MGC126776, PRO2249, DNA43
Protein Interaction Partner: CALCOCO2,CCDC85B,CCND1,CCND3,CDC45,CDC5L,CDC6,CDC7,CDK6,CDKN1A,CDKN2A,CEP70,CEP72,DPPA2,HAUS1,HOOK2,KRT15,MCM2,MCM3,MCM4,MCM6,MCM7,NINL,ORC2L,ORC3L,ORC4L,TRIM37,ZBTB43,ZBTB8B,CALCOCO2,CCDC85B,CCND3,CEP70,CEP72,DPPA2,HOOK2,KRT15,LMNB1,MCM6,MCM7,Mcm2,Mcm6,NINL,ORC2L,RPAP1,TRIM37,ZBTB43,ZBTB8A
Protein Size: 874 - Molecular Weight
- 98 kDa
- Gene ID
- 55388
- NCBI Accession
- NM_018518, NP_060988
- UniProt
- B7ZKZ8
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