Minichromosome Maintenance Deficient 4 (MCM4) Peptide
MCM4
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979898
Quick Overview for Minichromosome Maintenance Deficient 4 (MCM4) Peptide (ABIN979898)
Target
MCM4
(Minichromosome Maintenance Deficient 4 (MCM4))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM4 antibody (Catalog #: ARP36662_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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Background
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The protein encoded by MCM4 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
Alias Symbols: CDC21, CDC54, hCdc21, P1-CDC21
Protein Interaction Partner: MCM6,MCM7,MCM4,MCM6,MCM7,CCNA1,CDC5L,CDC7,CDK1,CDK2,MCM10,MCM2,MCM3,MCM4,MCM6,MCM7,MCM8,ORC2L,ORC6L,SSRP1,SUPT16H,CDC7,CDK2,CDT1,DBF4,ING5,MCM2,MCM4,MCM5,MCM6,MCM7,MCM8,ORC1L,ORC2L,ORC3L,ORC4L,ORC5L,ORC6L,RPA1,RPA2,USP7
Protein Size: 863 -
Molecular Weight
- 95 kDa
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Gene ID
- 4173
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NCBI Accession
- NM_182746, NP_877423
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UniProt
- P33991
Target
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