Minichromosome Maintenance Complex Component 7 (MCM7) (Middle Region) Peptide
MCM7
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN979904
Quick Overview for Minichromosome Maintenance Complex Component 7 (MCM7) (Middle Region) Peptide (ABIN979904)
Target
MCM7
(Minichromosome Maintenance Complex Component 7 (MCM7))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MCM7 antibody (Catalog #: ARP36666_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MCM7 (Minichromosome Maintenance Complex Component 7 (MCM7))
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Background
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MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: CDABP0042, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS-146, PNAS146
Protein Interaction Partner: RB1,RBL1,RBL2,MCM3,MCM4,MCM7,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDKN1B,CRLS1,DBF4,FHL2,HIST3H3,MBIP,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,NFKBIA,ORC1L,ORC2L,ORC3L,ORC4L,ORC5L,ORC6L,PLK1,RAD17,RB1,RBL1,RBL2,RBM8A,RPA1,SMC1A,UBE3A,ATR,ATRIP,CCNH,CDC45,CDC6,CDC7,CDK7,CDT1,CNOT8,DBF4,FHL2,GIPC1,GSTK1,MBIP,MCM10,MCM2,MCM3,MCM3,MCM4,MCM4,MCM5,MCM6,MCM7,MCM8,MNAT1,MYC,NEK6,ORC1L,ORC2L,ORC3L,ORC5L,PELO,RB1,RBL1,RBL2,RBM8A,RECQL5,RPA1,TH1L,TRAF6,UBE3A
Protein Size: 719 -
Molecular Weight
- 81 kDa
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Gene ID
- 4176
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NCBI Accession
- NM_005916, NP_005907
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UniProt
- P33993
Target
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