Mdc1 (MDC1) (C-Term) Peptide
MDC1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all MDC1 products
- MDC1 (Mdc1 (MDC1))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GKEEDVVTPK PGKRKRDQAE EEPNRIPSRS LRRTKLNQES TAPKVLFTGV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-MDC1 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MDC1 (Mdc1 (MDC1))
- Background
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The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
Alias Symbols: DKFZp781A0122, KIAA0170, MGC166888, NFBD1
Protein Interaction Partner: ATM,BARD1,BRCA1,CHEK2,CREBBP,EP300,H2AFX,MDC1,NBN,SMC1A,TP53,TP53BP1,USP28,ATM,BANF1,BRCA1,CENPC1,CHEK2,GATA4,H2AFX,HDAC10,HDAC8,MCPH1,MDM2,MRE11A,NBN,POLR2A,RAD50,RAD51,SUMO2,TP53,TP53BP1,UBC,USP28,WRN
Protein Size: 2089 - Molecular Weight
- 227 kDa
- Gene ID
- 9656
- NCBI Accession
- NM_014641, NP_055456
- UniProt
- Q14676
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