Mediator of Cell Motility 1 (MEMO1) (Middle Region) Peptide
MEMO1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN979984
Quick Overview for Mediator of Cell Motility 1 (MEMO1) (Middle Region) Peptide (ABIN979984)
Target
MEMO1
(Mediator of Cell Motility 1 (MEMO1))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CHWGQRFRYS YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Memo1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MEMO1 (Mediator of Cell Motility 1 (MEMO1))
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Background
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Memo1 may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. It is a mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Alias Symbols: 0610016J10Rik, D930048L02Rik
Protein Size: 297 -
Molecular Weight
- 34 kDa
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Gene ID
- 76890
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NCBI Accession
- NM_133771, NP_598532
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UniProt
- Q91VH6
Target
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