Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptide
MITF
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980098
Quick Overview for Microphthalmia-Associated Transcription Factor (MITF) (Middle Region) Peptide (ABIN980098)
Target
MITF
(Microphthalmia-Associated Transcription Factor (MITF))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-MITF antibody (Catalog #: ARP37978_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- MITF (Microphthalmia-Associated Transcription Factor (MITF))
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Background
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MITF is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: WS2A, MI, WS2, bHLHe32
Protein Interaction Partner: CTNNB1,EP300,FOS,GSK3B,LEF1,MAPK1,MAPK14,OTX2,PATZ1,PAX3,PAX6,PIAS3,RPS6KA1,SPI1,SUMO1,TFE3,TFEB,TFEC,UBE2I,CDK2,CDKN1A,FOS,LEF1,PATZ1,PAX6,PIAS3,RB1,SPI1,TFE3,TFEC,UBE2I
Protein Size: 419 -
Molecular Weight
- 47 kDa
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Gene ID
- 4286
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NCBI Accession
- NM_000248, NP_000239
Target
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