Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (N-Term) Peptide
NME1
Reactivity: Human
Host: Synthetic
BP, WB, DB, IHC
Catalog No. ABIN980764
Quick Overview for Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (N-Term) Peptide (ABIN980764)
Target
NME1
(Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NME1 antibody (Catalog #: AVARP00009_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
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Background
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This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
Alias Symbols: AWD, GAAD, NDPKA, NM23, NM23-H1, NB, NBS, NDKA, NDPK-A
Protein Interaction Partner: HHV4gp086,APEX1,AURKA,GORASP2,ITGB1,KSR1,MIF,NME1,NME3,NME4,POLR1C,PRUNE,RORA,RORB,RRAD,SET,TERF1,TIAM1,WDYHV1,AURKA,GORASP2,ITGB1,NME1,NME3,NME4,POLR1C,PRUNE,RAC1,RORA,RORB,RRAD,SET,TERF1,TIAM1,USP18,WDYHV1
Protein Size: 152 -
Molecular Weight
- 17 kDa
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Gene ID
- 4830
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NCBI Accession
- NM_000269, NP_000260
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UniProt
- P22392
Target
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