Non-POU Domain Containing, Octamer-Binding (NONO) Peptide
NONO
Reactivity: Human
Host: Synthetic
BP, WB, ICC
Catalog No. ABIN980800
Quick Overview for Non-POU Domain Containing, Octamer-Binding (NONO) Peptide (ABIN980800)
Target
NONO
(Non-POU Domain Containing, Octamer-Binding (NONO))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-NONO antibody (Catalog #: ARP40715_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
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Background
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NONO is DNA- and RNA binding protein, involved in several nuclear processes. It binds the conventional octamer sequence in double stranded DNA. It also binds single-stranded DNA and RNA at a site independent of the duplex site. It is involved in pre-mRNA splicing and interacts with U5 snRNA. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs, be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1 and be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
Alias Symbols: P54, NMT55, NRB54, P54NRB
Protein Interaction Partner: PCNA,SFPQ,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,POLR2A,PSPC1,SFPQ,SPI1,ZNRD1,AR,CA2,FXR2,MAD1L1,NONO,PIN1,PLEKHF2,PMS1,PSPC1,Polr2a,SFPQ,SOCS3,SPI1,ZNRD1
Protein Size: 471 -
Molecular Weight
- 52 kDa
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Gene ID
- 4841
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NCBI Accession
- NM_007363, NP_031389
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UniProt
- Q15233
Target
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