GTPase NRas (NRAS) (Middle Region) Peptide
NRAS
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN980946
Quick Overview for GTPase NRas (NRAS) (Middle Region) Peptide (ABIN980946)
Target
GTPase NRas (NRAS)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
-
-
Protein Region
- Middle Region
-
Sequence
- ADINLYREQI KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA HELAKSYGIP
-
Characteristics
- This is a synthetic peptide designed for use in combination with anti-NRAS Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
-
Purification
- Purified
-
-
-
-
Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
-
Concentration
- 1 mg/mL
-
Buffer
- Final peptide concentration is 1 mg/mL in PBS.
-
Handling Advice
- Avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
-
- GTPase NRas (NRAS)
-
Background
-
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Alias Symbols: ALPS4, N-ras, NRAS1, NS6
Protein Interaction Partner: RAF1,ACVR1,ARHGAP4,BCL2,PIK3CA,PLCE1,RACGAP1,RAF1,RAP1GDS1,RASGRP2,RASSF5,SHOC2,SMAD4,SMURF2,MLLT4,PIK3CG,PLCE1,RAF1,RAP1GDS1
Protein Size: 189 -
Molecular Weight
- 21 kDa
-
Gene ID
- 4893
-
NCBI Accession
- NM_002524, NP_002515
-
UniProt
- P01111
Target
-
You are here:
