2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2) Peptide
OAS2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981074
Quick Overview for 2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2) Peptide (ABIN981074)
Target
OAS2
(2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-OAS2 antibody (Catalog #: ARP40852_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- OAS2 (2'-5'-Oligoadenylate Synthetase 2, 69/71kDa (OAS2))
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Background
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OAS2 is a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. It is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication.This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
Alias Symbols: MGC78578
Protein Size: 719 -
Molecular Weight
- 82 kDa
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Gene ID
- 4939
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NCBI Accession
- NM_016817, NP_058197
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UniProt
- P29728
Target
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