Origin Recognition Complex, Subunit 6 (ORC6) Peptide
ORC6
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981203
Quick Overview for Origin Recognition Complex, Subunit 6 (ORC6) Peptide (ABIN981203)
Target
ORC6
(Origin Recognition Complex, Subunit 6 (ORC6))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ORC6L antibody (Catalog #: ARP55022_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ORC6 (Origin Recognition Complex, Subunit 6 (ORC6))
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Background
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The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ORC6, ORC6L
Protein Interaction Partner: CDC6,CDC7,MCM2,MCM4,MCM5,MCM6,MCM7,ORC2L,ORC3L,ORC4L,CDC45,CDC7,DBF4,MCM4,MCM5,ORC2L,ORC3L,ORC4L,ORC5L,RPA1,TERF2
Protein Size: 252 -
Molecular Weight
- 28 kDa
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Gene ID
- 23594
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NCBI Accession
- NM_014321, NP_055136
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UniProt
- Q9Y5N6
Target
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