Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1) Peptide
SUB1
Reactivity: Human
Host: Synthetic
BP, IHC, WB
Catalog No. ABIN981419
Quick Overview for Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1) Peptide (ABIN981419)
Target
SUB1
(Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PC4 antibody (Catalog #: P100960_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))
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Background
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PC4 (activated RNA polymerase II transcription cofactor 4) is a transcriptional coactivator, possessing the ability to suppress promoter-driven as well as nonspecific transcription via its DNA binding activity. The repressive activity of PC4 on promoter-driven transcription is alleviated by transcription factor TFIIH. TFIIH protects promoters from PC4-mediated repression by relieving the topological constraint imposed by PC4 through the ERCC3 helicase activity.
Alias Symbols: P15, PC4, p14
Protein Interaction Partner: CSTF2,IRF1,TERF2,ADAP1,CSNK2A1,CSTF2,EP300,GTF2A1L,HNF4A,HSF1,PCNA,POU2AF1,SUB1,TAF1,TBP,CSTF2,EP300,HNF4A,POU2AF1,PSIP1,SP1,SUB1,SUB1
Protein Size: 127 -
Molecular Weight
- 14 kDa
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Gene ID
- 10923
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NCBI Accession
- NM_006713, NP_006704
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UniProt
- P53999
Target
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