Proliferating Cell Nuclear Antigen (PCNA) Peptide
PCNA
Reactivity: Human
Host: Synthetic
BP, WB, IHC
Catalog No. ABIN981474
Quick Overview for Proliferating Cell Nuclear Antigen (PCNA) Peptide (ABIN981474)
Target
PCNA
(Proliferating Cell Nuclear Antigen (PCNA))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PCNA antibody (Catalog #: AVARP03018_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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Background
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PCNA is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.
Alias Symbols: MGC8367
Protein Interaction Partner: APEX2,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,DDX17,DNMT1,DSCC1,EXO1,FEN1,FEN1,FEN1,GADD45A,GADD45A,GADD45A,GADD45A,GADD45B,GADD45B,GADD45G,LIG1,MSH3,MSH6,MUTYH,MYBBP1A,NONO,PCNA,POLB,POLD1,POLD2,POLD3,POLDIP2,POLE,PRKDC,RFC2,RFC3,RFC5,TCOF1,UNG,BAZ1B,KCTD13,APEX1,APEX2,BAZ1B,CCNB1,CCND1,CCND3,CCNO,CDC25C,CDC6,CDK1,CDK2,CDK5,CDK6,CDKN1A,CDKN1C,CDT1,CHAF1A,CHTF18,CHTF8,DHX9,DNMT1,DNTT,DNTTIP2,DSCC1,EP300,ERCC5,FEN1,GADD45A,GADD45B,GADD45G,HDAC1,HUS1,ING1,KCTD13,LIG1,MCL1,MSH2,MSH3,MSH6,MUTYH,MYBBP1A,PARP1,PCNA,POLB,POLD1,POLD2,POLD3,POLD4,POLDIP2,POLE,POLH,POLI,POLL,POLM,PPP1CA,PRKDC,PTMA,RAD9A,RBBP8,RFC1,RFC2,RFC3,RFC4,RFC5,RPA1,SEC23IP,SUB1,TCOF1,UBB,UNG,WRN,XRCC1,XRCC5,XRCC6,YBX1,AIRE,ANXA2,APEX1,APEX2,CCNA2,CCND1,CCND3,CCNO,CDC25C,CDC6,CDK2,CDK4,CDKN1A,CDKN1C,CDT1,CHAF1A,CHTF18,CLSPN,CUL4A,DDB1,DNMT1,DNTT,EP300,ERCC5,FEN1,GADD45A,GADD45G,Gadd45b,HDAC1,HLTF,HUS1,ING1,KCTD13,KIAA0101,LIG1,MCL1,MSH2,MSH3,MSH6,MUTYH,MYBBP1A,OTUB1,PARP1,PCNA,PMS2,POLD1,POLD2,POLD3,POLDIP2,POLE,POLH,POLL,PRKDC,Polk,RFC1,RFC2,RFC3,RFC4,RFC5,RPA1,RUVBL2,SMARCA4,TIMELESS,UBC,WRN,XRCC1,XRCC5,XRCC6,YBX1
Protein Size: 261 -
Molecular Weight
- 29 kDa
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Gene ID
- 5111
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NCBI Accession
- NM_002592, NP_002583
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UniProt
- P12004
Target
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