PDZ Domain Containing 1 (PDZK1) (N-Term) Peptide
PDZK1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981569
Quick Overview for PDZ Domain Containing 1 (PDZK1) (N-Term) Peptide (ABIN981569)
Target
PDZK1
(PDZ Domain Containing 1 (PDZK1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- NSVTLLVLDG DSYEKAVKTR VDLKELGQSQ KEQGLSDNIL SPVMNGGVQT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PDZK1 Antibody(ARP41506_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PDZK1 (PDZ Domain Containing 1 (PDZK1))
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Background
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PDZK1 is a scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. It may be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, it may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. PDZK1 may play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. PDZK1 may potentiate the CFTR chloride channel activity. It may function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. PDZK1 may be involved in the regulation of proximal tubular Na+-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
Alias Symbols: CAP70, CLAMP, NHERF3, PDZD1, NHERF-3
Protein Interaction Partner: ABCA1,ABCC2,AKAP10,CFTR,CLCN3,GFAP,PDZK1IP1,PEX5,SCARB1,SLC15A2,SLC17A1,SLC22A11,SLC22A12,SLC22A4,SLC22A5,SLC26A6,SLC9A3,SLCO1A2,SSTR5,ABCC2,AKAP10,CFTR,CLCN3,FARP2,GFAP,PDZK1IP1,PEX5,SCARB1,SLC17A1,SLC22A12,SLC22A4,SLC34A3,SLC9A3,SLC9A3R1,SLC9A3R2,SLK,UB
Protein Size: 519 -
Molecular Weight
- 57 kDa
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Gene ID
- 5174
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NCBI Accession
- NM_002614, NP_002605
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UniProt
- Q5T2W1
Target
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