Protein Inhibitor of Activated STAT, 2 (PIAS2) Peptide
PIAS2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981732
Quick Overview for Protein Inhibitor of Activated STAT, 2 (PIAS2) Peptide (ABIN981732)
Target
PIAS2
(Protein Inhibitor of Activated STAT, 2 (PIAS2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PIAS2 antibody (Catalog #: ARP53840_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
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Background
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Pias2 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It seems to be mostly involved in gene silencing. It binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. This gene encodes a protein involved in the regulation of transcription factors involved in MAP kinase signaling. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. Two alternatively spliced transcripts encoding different isoforms have been described.
Alias Symbols: MGC102682, MIZ1, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4, miz, DIP, MIZ, ARIP3, PIASX
Protein Interaction Partner: GTF2IRD1,HTNVsSgp1,SUMO1,UBE2I,ELK1,AR,BAT1,CHMP4B,ELK1,GRM8,GTF2I,GTF2IRD1,HDAC3,MBD1,MSX2,NAV2,PARK7,PIAS1,SMAD4,SNIP1,STAT4,SUMO1,UBE2I,AKT1,AKT1,AR,CDKN1A,CDKN1A,CDKN1C,CDKN2B,CDV3,DNMT3A,ESR1,ESR2,GTF2IRD1,ITGB5,MYC,NAV2,NR3C1,PARK7,PGR,SIAH1,SIAH2,STAT4,SUMO1,UBE2I,YWHAH
Protein Size: 572 -
Molecular Weight
- 63 kDa
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Gene ID
- 9063
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NCBI Accession
- NM_173206, NP_775298
Target
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