Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H) Peptide
POLR2H
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN981963
Quick Overview for Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H) Peptide (ABIN981963)
Target
POLR2H
(Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-POLR2H antibody (Catalog #: ARP48697_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POLR2H (Polymerase (RNA) II (DNA Directed) Polypeptide H (POLR2H))
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Background
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POLR2H is one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III.This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed RNA polymerases, I and III. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-400 AU142999.1 1-400 401-907 BI772069.1 287-793 908-1792 BC008348.1 928-1812 1793-3185 AC099344.4 111461-112853 c
Alias Symbols: RPABC3, RPB17, RPB8, hsRPB8
Protein Interaction Partner: POLR2A,POLR2A,POLR2B,POLR2B,POLR2C,POLR2D,POLR2E,POLR2G,POLR2H,POLR2K,POLR2L,NFKBIB,POLR2A,POLR2B,POLR2C,POLR2D,POLR2E,POLR2G,POLR2H,POLR2I,POLR2K,POLR2L,CD40,GTF2B,GTF2F2,MED10,MED19,MED26,MED29,NME2,POLR2A,POLR2B,POLR2C,POLR2E,POLR2G,POLR2H,POLR2J,POLR2K,POLR2L,POLR3D,POLR3H,RPAP2,RUVBL2
Protein Size: 150 -
Molecular Weight
- 17 kDa
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Gene ID
- 5437
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NCBI Accession
- NM_006232, NP_006223
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UniProt
- P52434
Target
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