Peroxisome Proliferator-Activated Receptor delta (PPARD) Peptide
PPARD
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982040
Quick Overview for Peroxisome Proliferator-Activated Receptor delta (PPARD) Peptide (ABIN982040)
Target
PPARD
(Peroxisome Proliferator-Activated Receptor delta (PPARD))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PPARD antibody (Catalog #: ARP32878_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))
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Background
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PPARD is a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR delta and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
Alias Symbols: FAAR, NUC1, NUCI, NR1C2, NUCII, PPARB
Protein Interaction Partner: BCL6,HDAC7,NCOR2,BCL6,DUT,EP300,GADD45B,GADD45G,HDAC1,HDAC2,HDAC3,HDAC7,NCOR1,NCOR2,NR0B2,NRIP1,PEBP1,PPARD,PRDX6,PROX1,RANBP9,RXRA,RXRB,RXRG,SMAD9,SPEN,SRC,CEP350,GADD45G,Gadd45b,HDAC1,HDAC2,HDAC3,HDAC4,NCOR1,NCOR2,PPARD,SPEN
Protein Size: 441 -
Molecular Weight
- 49 kDa
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Gene ID
- 5467
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NCBI Accession
- NM_006238, NP_006229
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UniProt
- Q03181
Target
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