Preferentially Expressed Antigen in Melanoma (PRAME) (N-Term) Peptide
PRAME
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982157
Quick Overview for Preferentially Expressed Antigen in Melanoma (PRAME) (N-Term) Peptide (ABIN982157)
Target
PRAME
(Preferentially Expressed Antigen in Melanoma (PRAME))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PRAME antibody (Catalog #: ARP55982_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PRAME (Preferentially Expressed Antigen in Melanoma (PRAME))
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Background
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PRAME functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. PRAME prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: MAPE, OIP4, CT130
Protein Interaction Partner: STK19,STK19
Protein Size: 509 -
Molecular Weight
- 56 kDa
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Gene ID
- 23532
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NCBI Accession
- NM_006115, NP_006106
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UniProt
- P78395
Target
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