Protein Kinase C, eta (PRKCH) (N-Term) Peptide
PRKCH
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982217
Quick Overview for Protein Kinase C, eta (PRKCH) (N-Term) Peptide (ABIN982217)
Target
PKC eta (PRKCH)
(Protein Kinase C, eta (PRKCH))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- KKGHQLLDPY LTVSVDQVRV GQTSTKQKTN KPTYNEEFCA NVTDGGHLEL
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PRKCH Antibody(ARP56703_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
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Background
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Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
Alias Symbols: MGC26269, MGC5363, PKC-L, PKCL, PRKCL, nPKC-eta
Protein Interaction Partner: AKAP13,PDPK1,PRKCH,PRKD1,CDK2,FYN,ITGB2,NUMB,PARD6A,PRKD1,PTPN11,SRC,CDK2,ZBTB8OS
Protein Size: 683 -
Molecular Weight
- 78 kDa
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Gene ID
- 5583
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NCBI Accession
- NM_006255, NP_006246
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UniProt
- P24723
Target
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