Protein Arginine Methyltransferase 7 (PRMT7) (C-Term) Peptide
PRMT7
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN982241
Quick Overview for Protein Arginine Methyltransferase 7 (PRMT7) (C-Term) Peptide (ABIN982241)
Target
PRMT7
(Protein Arginine Methyltransferase 7 (PRMT7))
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- GEINDQDRTD HYAQALRTVL LPGSVCLCVS DGSLLSMLAH HLGAEQVFTV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Prmt7 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PRMT7 (Protein Arginine Methyltransferase 7 (PRMT7))
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Background
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Prmt7 is a arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. It plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. It may also play a role in embryonic stem cell (ESC) pluripotency. It also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro, the relevance of such results is however unclear in vivo.
Alias Symbols: 4933402B05Rik, BC006705, MGC7929
Protein Size: 692 -
Molecular Weight
- 78 kDa
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Gene ID
- 214572
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NCBI Accession
- NM_145404, NP_663379
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UniProt
- Q922X9
Target
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