Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) Peptide
PSENEN
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982323
Quick Overview for Presenilin Enhancer 2 Homolog (PSENEN) (C-Term) Peptide (ABIN982323)
Target
PEN2 (PSENEN)
(Presenilin Enhancer 2 Homolog (PSENEN))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SQIKGYVWRS AVGFLFWVIV LTSWITIFQI YRPRWGALGD YLSFTIPLGT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PSENEN Antibody(ARP59439_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PEN2 (PSENEN) (Presenilin Enhancer 2 Homolog (PSENEN))
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Background
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Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
Alias Symbols: MDS033, MSTP064, PEN-2, PEN2
Protein Interaction Partner: APH1A,NCSTN,PSEN1,APH1A,NCSTN,PSEN1,PSEN2,TMED10,APH1A,NCSTN,PSEN1,PSEN2
Protein Size: 101 -
Molecular Weight
- 12 kDa
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Gene ID
- 55851
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NCBI Accession
- NM_172341, NP_758844
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UniProt
- Q9NZ42
Target
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