Retinoic Acid Receptor, alpha (RARA) (Middle Region) Peptide
RARA
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982661
Quick Overview for Retinoic Acid Receptor, alpha (RARA) (Middle Region) Peptide (ABIN982661)
Target
Retinoic Acid Receptor alpha (RARA)
(Retinoic Acid Receptor, alpha (RARA))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RARA antibody (Catalog #: P100861_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Retinoic Acid Receptor, alpha (RARA) peptide
RARA Reactivity: Human, Mouse, Cow, Dog, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))
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Background
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Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor, which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT, and histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.
Alias Symbols: NR1B1, RAR
Protein Interaction Partner: NCOR1,NCOR2,ANP32A,BTG1,CDK7,KDM5A,MED6,NCOA1,NCOA2,NCOA3,PARP1,PRMT2,TNFRSF10B,BAG1,BTG1,CCND3,CDK7,CNOT1,COPS2,ESR1,FOXO1,GADD45G,GATA2,IRX4,ITGB1BP2,KAT2B,KDM5A,KLF5,MECR,MED1,MED6,NCOA1,NCOA3,NCOA6,NCOR1,NCOR2,NKX2-1,NPAS2,NR0B2,NR1H2,NR1H3,NR2E3,NRBF2,NRIP1,NRIP2,NSD1,PARP1,PML,PNRC2,POU2F1,PRDX6,PRKCA,RXRA,RXRB,RXRG,SNW1,SP1,SPEN,STAT5B,TADA3,TRIM24,TRIP4,UBE3A,ZBTB16,ARNTL,BAG1,CCND3,CLOCK,GADD45A,GADD45G,Gadd45b,HDAC3,HDAC4,IRX4,JUB,KAT2B,KDM5A,LIMD1,MECR,NCOA2,NCOA6,NCOR1,NCOR2,NKX2-1,NPAS2,NR0B2,NR2E3,NR4A2,NRBF2,NRIP1,Nr0b2,Nsd1,PML,POU2F1,RARA,RXRA,RXRB,RXRG,SKI,SP1,SRC,TADA3,TDG,TRIM24,TRIP4,WTIP,ZBTB16
Protein Size: 462 -
Molecular Weight
- 51 kDa
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Gene ID
- 5914
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NCBI Accession
- NM_000964, NP_000955
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UniProt
- P10276
Target
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