Retinoblastoma-Like 1 (p107) (RBL1) (N-Term) Peptide
RBL1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN982718
Quick Overview for Retinoblastoma-Like 1 (p107) (RBL1) (N-Term) Peptide (ABIN982718)
Target
p107 (RBL1)
(Retinoblastoma-Like 1 (p107) (RBL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-RBL1 antibody (Catalog #: P100682_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))
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Background
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RBL1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: CP107, MGC40006, PRB1, p107
Protein Interaction Partner: RB1,E2F1,E2F2,E2F4,RBL2,E2F4,BEGAIN,BRF1,CCNA1,CCNA2,CCND1,CCNE1,CDK2,CDK4,CEBPA,CREG1,DGKZ,DHX30,E2F4,E2F5,HDAC1,ID2,KDM5A,MCM7,MYBL2,MYC,NR2E3,PHB,PPP2R3A,RBBP8,RBBP9,RBL1,SMAD2,SMAD3,SMAD4,SNW1,SP1,SUV39H1,SUV420H2,TAF1,USP4,AATF,ARID4A,BEGAIN,BRCA1,BRF1,CCNA1,CCNA2,CCNE1,CDK2,CDKN1C,CREG1,E2F1,E2F4,E2F5,HDAC1,HDAC2,HDAC3,KDM5A,LIN9,MCM7,MCM7,MT1G,MYBL2,MYC,PHB,PPP2R3A,RB1,RBBP8,RBBP9,SMAD3,SMAD4,SNW1,SUV39H1,TAF1,TFDP1,TFDP2,USP4,UXT
Protein Size: 1014 -
Molecular Weight
- 115 kDa
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Gene ID
- 5933
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NCBI Accession
- NM_183404, NP_899662
Target
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