Renalase, FAD-Dependent Amine Oxidase (RNLS) (Middle Region) Peptide
RNLS
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all RNLS products
- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- GMKIGVPWSC RYLSSHPCIC FISIDNKKRN IESSECGPSV VIQTTVPFGV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Rnls Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
- Background
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Rnls is a probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. It degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
Alias Symbols: 6530404N21Rik, AI452315, AW060440, C10orf59
Protein Size: 300 - Molecular Weight
- 33 kDa
- Gene ID
- 67795
- NCBI Accession
- NM_001167818, NP_001161290
- UniProt
- A7RDN6
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