SH3 Domain Containing Ring Finger 1 (SH3RF1) (Middle Region) Peptide
SH3RF1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983699
Quick Overview for SH3 Domain Containing Ring Finger 1 (SH3RF1) (Middle Region) Peptide (ABIN983699)
Target
SH3RF1
(SH3 Domain Containing Ring Finger 1 (SH3RF1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SH3RF1 antibody (Catalog #: ARP43283_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SH3RF1 (SH3 Domain Containing Ring Finger 1 (SH3RF1))
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Background
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SH3RF1 acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling complex, it probably recruits protein kinases such as MAP3K10 or MAP3K11 which are in turn activated leading to the sequential activation of MAP2K4, MAP2K7 and JNKs (MAPK8 and MAPK9). SH3RF1 may be involved in targeting of HIV-1 GAG and GAG-POL polyproteins to the plasma membrane.This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
Alias Symbols: FLJ21602, KIAA1494, POSH, RNF142, SH3MD2
Protein Interaction Partner: ADAM15,AKT2,MAP3K10,MAP3K11,MAP3K12,MAP3K9,PAK2,RACGAP1,SEMA6A,SIAH1,AKT2,MAP3K11
Protein Size: 888 -
Molecular Weight
- 93 kDa
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Gene ID
- 57630
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NCBI Accession
- NM_020870, NP_065921
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UniProt
- Q7Z6J0
Target
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