SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Peptide
SHC1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN983706
Quick Overview for SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1) Peptide (ABIN983706)
Target
SHC1
(SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SHC1 antibody (Catalog #: ARP50490_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SHC1 (SHC (Src Homology 2 Domain Containing) Transforming Protein 1 (SHC1))
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Background
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SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.
Alias Symbols: FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Protein Interaction Partner: AXL,DDR1,EGFR,EGFR,EGFR,EGFR,GRB2,GRB2,IGF1R,INPP5D,INSR,ITGB3,NTRK1,NTRK1,PDGFRB,PDGFRB,RET,SRC,IRS1,PDGFRB,NTRK1,ALK,AP2A1,AP2A2,APP,AXL,BCL3,BCR,CALCOCO2,CALD1,CBL,CBLB,CD22,CD247,CD3E,CD81,CDH5,CEACAM1,CRK,CRKL,CSF1R,CSF2RB,CSF3R,CSK,DAG1,DDR1,DDR2,DOK1,EGFR,EPHA2,EPOR,EPS8,ERBB2,ERBB3,ERBB4,ESR1,FCGR2A,FCGR3A,FGFR1,FLT1,FLT4,FYN,GAB1,GAB2,GHR,GRAP,GRAP2,GRB2,GRB7,IL2,IL2RB,IL2RG,IL4R,INPP5D,INPPL1,INSR,IRS1,IRS2,ITGB3,ITGB4,JAK2,KDR,KRT18,LCK,LCP2,LRP1,LTK,LYN,MAP4K1,MAPK1,MAPK14,MAPK8,MAPKAPK2,MET,MME,MPL,MST1R,NGFR,NPM1,NTRK1,NTRK2,NTRK3,PAG1,PAK1,PDGFRB,PIK3R1,PIK3R2,PLCG1,PLCG2,PLSCR1,PPAP2B,PPP2R5A,PRKCA,PRKCD,PTK2,PTK2B,PTPN11,PTPN12,PTPN2,PTPN6,RAPGEF1,RASA1,RET,SH2B2,SHCBP1,SOS1,SOS2,SP1,SRC,STAT5A,STAT5B,SYK,TEC,TEK,TPR,VAV1,VAV3,ZAP70,GRB2,ABL1,ALK,AP2A2,APP,CALCOCO2,CALD1,CBL,CBLB,CD22,CDH5,CEACAM1,CRKL,CSF2RB,CSF3R,CSK,Cd3e,DAG1,DDR1,DDR2,DOK1,DOK2,EGFR,EPHA2,EPOR,EPS8,ERBB2,ERBB3,ERBB4,ESR1,FCGR2B,FLT1,FLT4,GAB2,GH1,GHR,GRB2,Gab2,Grap2,IGF1R,IL2RB,IL2RG,IL4R,IL6ST,INPP5D,INPPL1,INSR,IRS1,ITGB4,JAK2,KDR,LRP1,LYN,MAPK1,MAPKAPK2,MET,MST1R,NGFR,NTRK1,NTRK2,NTRK3,PAG1,PDGFRB,PIK3C2B,PIK3R1,PIK3R1,PLCG1,PLCG2,PLSCR1,PRKCD,PTK2,PTK2,PTPN12,Ptpn12,RAPGEF1,RET,SHCBP1,SOS1,SOS2,STAT5A,STAT5B,VAV3,ZAP70
Protein Size: 474 -
Molecular Weight
- 52 kDa
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Gene ID
- 6464
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NCBI Accession
- NM_003029, NP_003020
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UniProt
- P29353
Target
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