SIX Homeobox 1 (SIX1) (N-Term) Peptide
SIX1
Reactivity: Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN983779
Quick Overview for SIX Homeobox 1 (SIX1) (N-Term) Peptide (ABIN983779)
Target
SIX Homeobox 1 (SIX1)
Origin
Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- ERLGRFLWSL PACDHLHKNE SVLKAKAVVA FHRGNFRELY KILESHQFSP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Six1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- SIX Homeobox 1 (SIX1)
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Background
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Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
Alias Symbols: BB138287
Protein Size: 284 -
Molecular Weight
- 32 kDa
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Gene ID
- 20471
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NCBI Accession
- NM_009189, NP_033215
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UniProt
- Q62231
Target
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