SMAD Family Member 4 (SMAD4) Peptide
SMAD4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SMAD4 products
- SMAD4 (SMAD Family Member 4 (SMAD4))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SMAD4 antibody (Catalog #: ARP32005_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SMAD4 (SMAD Family Member 4 (SMAD4))
- Background
-
SMAD4 is one of the Smad family members, which are essential intracellular signalling components of the transforming growth factor-beta (TGF-beta) superfamily. Smad2 and Smad3 are structurally highly similar and mediate TGF-beta signals. Smad4 is distantly related to Smads 2 and 3, and forms a heteromeric complex with Smad2 after TGF-beta or activin stimulation. TGF-beta induces heteromeric complexes of Smads 2, 3 and 4, and their concomitant translocation to the nucleus, which is required for efficient TGF-beta signal transduction
Alias Symbols: JIP, DPC4, MADH4, MYHRS
Protein Interaction Partner: BRCA1,CDKN1A,CEBPB,FOXO1,FOXO3,FOXO4,SKI,SKI,SKIL,SMAD1,SMAD2,SMAD2,SMAD3,SMAD3,STUB1,SUMO1,TGFB1I1,TGFBR1,TGFBR2,TRIM33,TSSK3,ACVR1B,AKT1,AP2B1,APBB2,AR,ARFRP1,ARL5B,ATF2,ATF7IP,BRCA1,BTRC,C16orf57,CAMK2G,CD59,CEBPB,CHEK1,CITED1,CNKSR1,COPS5,CREBBP,CSH1,CTCF,CTNNB1,DACH1,DCP1A,DCP1B,DLX1,DNAJB2,DVL1,ECSIT,EEF1A1,EID2,EIF2AK4,EP300,ERBB2IP,ESR1,ESR2,EWSR1,FBLN1,FBXO30,FBXO34,FN1,FOXG1,FOXH1,FOXO1,FOXO3,FOXO4,FSTL3,GLI3,GPNMB,HDGF,HDLBP,HMG20A,HNF4A,HOXA9,HOXC8,ITK,JUN,JUNB,JUND,LEF1,MAPK1,MAPK13,MAX,MEF2A,MEX3B,MYOD1,NAT8,NEK6,NOTCH4,NRAS,NUAK2,NUP214,OCLN,ODZ3,PAK1,PAPPA2,PARD3,PBK,PIAS1,PIAS2,PIAS3,PIAS4,PLK4,PRKAR1B,PRKAR2A,PRPF40A,PSG2,PSG9,PSMD11,RAB13,RAB25,RAB2B,RAB34,RAB38,RAB3B,RAC2,RALA,RASD2,RASL12,RBL1,RFX1,RHEBL1,RHOD,RHOG,RHOJ,RIPK2,RMND5B,RPL28,RPS27A,RRAS2,RTDR1,SASH3,SKI,SKIL,SMAD1,SMAD2,SMAD3,SMAD4,SMAD5,SMAD9,SNIP1,SNRNP70,SP1,SPTBN1,SQSTM1,STK11IP,STK35,STUB1,TCTA,TDG,TFE3,TGFBR1,TGFBR2,TGFBRAP1,TH1L,TM9SF2,TOB1,TRAP1,TSSK3,UBA52,UBB,UBE2I,UBE2L3,UBE2Z,UHRF2,XPO5,ZBED5,ZMYM2,ZNF423,ZNF521,ZNF8,AKT1,AR,ATF2,Ap2b1,Apbb2,Arfrp1,Arhgef11,Arhgef7,Arl5b,BTRC,CAMK2G,CEBPA,CEBPB,CEBPD,CITED1,COPS5,CTNNB1,Chek1,DCP1A,DLX1,DVL1,EID2,EP300,EP300,ERBB2IP,EWSR1,Eif2ak4,FOXH1,FOXO1,FOXO3,FOXO4,HOXA9,HOXC8,Hdgf,Ilkap,Itk,JUNB,KPNB1,LEF1,MAX,MDM4,Map2k3,Nek6,Nras,Nuak2,Ocln,PARD3B,PIAS3,PIAS4,Pbk,Plk4,RBL1,Rab13,Rab2b,Rab34,Rab38,Rab3b,Rac2,Rasd2,Rhod,Rhog,Rhoj,Ripk2,Rnf138,Rnf14,Rps27a,Rras2,Rtdr1,SKI,SKIL,SMAD1,SMAD2,SMAD3,SMAD5,SMAD6,SMAD7,SMAD9,SNIP1,SNW1,STK11IP,Smad1,Smad2,Smad3,Sqstm1,Stat1,Stk35,TFE3,TGFBR1,TGFBRAP1,TOB1,Trim35,Tssk3,UBE2I,Ubb,Uhmk1,ZNF423,Zfp128
Protein Size: 552 - Molecular Weight
- 60 kDa
- Gene ID
- 4089
- NCBI Accession
- NM_005359, NP_005350
- UniProt
- Q13485
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