Thyroid Hormone Receptor, beta (THRB) (Middle Region) Peptide
THRB
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN985077
Quick Overview for Thyroid Hormone Receptor, beta (THRB) (Middle Region) Peptide (ABIN985077)
Target
THRB
(Thyroid Hormone Receptor, beta (THRB))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-THRB antibody (Catalog #: ARP37995_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Thyroid Hormone Receptor, beta (THRB) peptide
THRB Reactivity: Zebrafish (Danio rerio) Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- THRB (Thyroid Hormone Receptor, beta (THRB))
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Background
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THRB is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been determined so far. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.
Alias Symbols: ERBA-BETA, ERBA2, GRTH, MGC126109, MGC126110, NR1A2, THR1, THRB1, THRB2, PRTH, C-ERBA-2, C-ERBA-BETA
Protein Interaction Partner: ANP32A,BTG1,CTCF,MED21,MPG,NCOA1,NCOA2,NCOA3,NCOA3,PRMT2,RXRB,ACVR1,BRD8,BTG1,C1D,CAMK2B,CCND1,CNOT1,COPS2,CTCF,ESR1,FOXO1,HDAC2,HMGN3,JMJD1C,MECR,MED1,MED21,MPG,NCOA1,NCOA2,NCOA3,NCOA6,NCOR1,NCOR2,NR2F6,NRBF2,NRIP1,PPARGC1A,PRMT2,PSMC3IP,PSMC5,RXRA,RXRB,RXRG,THRB,TP53,TRIP10,TRIP12,TRIP13,TRIP4,TRIP6,ZNHIT3,BRD8,CCND1,COPS2,EIF3I,Hdac2,NCOA1,NCOA2,NCOA6,NCOR2,NR2F6,NRBF2,PPARGC1A,PPARGC1B,PRMT1,PSMC5,RXRA,SRC,TBL1X,THRB,TP53,TRIP4,TSG101
Protein Size: 461 -
Molecular Weight
- 53 kDa
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Gene ID
- 7068
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NCBI Accession
- NM_000461, NP_000452
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UniProt
- P10828
Target
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