Toll-Like Receptor 4 (TLR4) (C-Term) Peptide
TLR4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all TLR4 products
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QQVELYRLLS RNTYLEWEDS VLGRHIFWRR LRKALLDGKS WNPEGTVGTG
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TLR4 Antibody,. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Toll-Like Receptor 4 (TLR4) (AA 420-435) peptide (Ovalbumin)
TLR4 Reactivity: Human Host: Synthetic WB, Imm, SDS
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TLR4 (Toll-Like Receptor 4 (TLR4))
- Background
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The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Alias Symbols: ARMD10, CD284, TOLL, hToll
Protein Interaction Partner: BCL10,BTK,CD14,CNPY4,DEFB4A,HMGB1,HSP90B1,IRAK1,IRAK2,LY96,MAPK8IP3,MYD88,NOX4,RIPK2,RNF216,SIGIRR,SYK,TICAM2,TIRAP,TLR1,TLR5,TOLLIP,ECSIT,LY96,LY96,MYD88,PPP4C,RNF216,SIGIRR,TIRAP,TLR1,TOLLIP
Protein Size: 839 - Molecular Weight
- 93 kDa
- Gene ID
- 7099
- NCBI Accession
- NM_138554, NP_612564
- UniProt
- O00206
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