Tumor Protein P53 (TP53) (N-Term) Peptide
TP53
Reactivity: Human
Host: Synthetic
BP, WB, ChIP, IHC
Catalog No. ABIN985382
Quick Overview for Tumor Protein P53 (TP53) (N-Term) Peptide (ABIN985382)
Target
p53 (TP53)
(Tumor Protein P53 (TP53))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Chromatin Immunoprecipitation (ChIP), Immunohistochemistry (IHC)
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Protein Region
- N-Term
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TP53 antibody (Catalog #: ARP30307_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- p53 (TP53) (Tumor Protein P53 (TP53))
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Background
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TP53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Alias Symbols: LFS1, TRP53, p53
Protein Interaction Partner: BAK1,BCL6,APEX1,ATF3,ATM,ATM,ATM,ATM,ATR,AURKA,BAK1,BARD1,BAX,BAX,BAX,BCL2L1,BLM,BLM,BLM,BNIP3L,BRCA1,BRCA1,CARM1,CDC25C,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CDKN1A,CR2,CREBBP,CUL9,DDX5,DHCR24,EP300,EP300,EP300,ERCC3,ESR1,FOXO3,GPS2,GSK3B,HCVgp1,HCVgp1,HCVgp1,HCVgp1,HCVgp1,HIF1A,HIF1A,HIF1A,HIPK2,HMGB1,HSPA8,HSPA8,HTT,HTT,HUWE1,ING1,ING4,ING5,Jvgp5,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MDM2,MRE11A,MSX1,MTA2,MUC1,NR3C1,NTHL1,PIAS1,PPP1R13L,PPP2CA,PRMT1,PTGS2,PTTG1,RECQL4,RFWD2,SFN,SFN,SIN3A,SMG1,SP1,SP1,SP1,SP1,SUMO1,SV40gp6,SV40gp6,TFAP2A,TFAP2C,TNFRSF10B,TNFRSF10C,TOPORS,TP53,TP53,TP53,TP53I3,TXN,UBE2I,UBE2I,USP7,WRN,XRCC6,YY1,nef,nef,ABL1,ACTA1,ANKRD2,ANXA3,APEX1,ARID3A,ARIH2,ARL3,ATF3,ATM,ATR,AURKA,BAK1,BANP,BARD1,BCL2,BCL2L1,BCR,BLM,BRCA1,BRCA2,BRF1,BTBD2,BTK,CABLES1,CABLES2,CAPN1,CCDC106,CCL18,CCNA2,CCNG1,CCNH,CCT5,CD40LG,CDC14A,CDC14B,CDC25C,CDC42,CDK1,CDK2,CDK5,CDK9,CDKN2C,CEBPZ,CHD3,CHEK1,CHEK2,CHUK,COPS2,COPS3,COPS4,COPS5,COPS6,COPS7A,COPS8,COX17,CR2,CREBBP,CSNK1A1,CSNK1D,CSNK2A1,CSNK2B,CUL9,DAXX,DDX5,DHCR24,DVL2,E2F1,E4F1,EEF2,EFEMP2,EGR1,EIF2AK2,EIF2S2,ELL,EP300,EPHA3,ERCC3,ERCC6,ERH,ESR1,FAM173A,FBXO11,FXYD6,GNL3,GPS1,GPS2,GSK3B,GSTM4,GTF2H1,GUSBP1,HABP4,HDAC1,HDAC2,HDAC3,HIF1A,HIPK1,HIPK2,HMGB1,HMGB2,HNF4A,HSP90AA1,HSP90AB1,HSPA1A,HSPA9,HSPB1,HTT,HUWE1,IFI16,ING1,ING4,ING5,KAT2B,KAT5,KLF4,KLF6,KPNA2,KPNB1,LAMA4,MAD2L1BP,MAGEB18,MAPK1,MAPK10,MAPK3,MAPK8,MAPK9,MAPKAPK5,MDC1,MDM2,MDM4,MED1,MED17,MIF,MNAT1,MNDA,MPHOSPH6,MSX1,MTA1,MTA2,NAP1L1,NCL,NDN,NEDD8,NFKBIA,NFYA,NFYB,NMT1,NMT2,NPM1,NQO1,NR3C1,NR4A1,PAFAH1B3,PARP1,PBK,PCDHA4,PHB,PIAS1,PIAS4,PIN1,PLAGL1,PLK1,PLK3,PML,PNP,POLA1,PPA1,PPP1CA,PPP1CC,PPP1R13L,PPP2CA,PPP2R2B,PRIM1,PRKCA,PRKDC,PRKRA,PRMT1,PSMD11,PTEN,PTGS2,PTK2,PTTG1,RAB4A,RAD51,RCHY1,RFWD2,RPA1,RRM2,RRM2B,S100A2,S100A4,S100A8,S100B,SAT1,SCAMP1,SERPINB9,SETD7,SHISA5,SIN3A,SIRT1,SMAD2,SMAD3,SMARCA4,SMARCB1,SMN2,SMYD2,SNRPN,SP1,SP3,SSTR3,STK11,STK4,STRA13,STX5,SULT1E1,SUMO1,SYVN1,TADA3,TAF1A,TAF1B,TAF1C,TAF9,TAF9B,TBP,TEC,TEP1,TFAP2A,TFAP2C,TFDP1,THAP8,THRB,TK1,TOP1,TOP2A,TOP2B,TOPORS,TP53,TP53BP1,TP53BP2,TP53INP1,TP53RK,TP63,TP73,TRIAP1,TSG101,UBB,UBE2A,UBE2I,UBE2K,UBE3A,USP7,VRK1,WDR33,WRN,WT1,WWOX,XRCC6,YBX1,YWHAG,YWHAZ,ZCCHC10,ZHX1,ZNF148,ZNF24,ZNHIT1,ABL1,AIMP2,ANKRD2,ANXA3,APEX1,APTX,AR,ARIH2,ARL3,ATF3,ATM,ATR,AURKA,BAG1,BAK1,BARD1,BCR,BLM,BRCA1,BRCA2,BRCC3,BRE,BRF1,BTBD2,Banp,CA11,CABLES1,CABLES2,CARM1,CCAR1,CCDC106,CCL18,CCNA2,CCNG1,CCNH,CCT5,CDC14A,CDC14B,CDC42,CDK1,CDK2,CDK5,CDK7,CDK9,CDKN1A,CDKN2A,CDKN2C,CEBPZ,CFLAR,CHD3,CHD8,CHEK1,COPS5,COX17,CREB1,CREBBP,CUL9,DAPK1,DHFR,DLEU1,DVL2,E4F1,EEF2,EFEMP2,EGR1,EIF2AK2,EIF2S2,ELL,EP300,EPHA3,ERCC2,ERCC3,ERCC6,ERH,ESR1,ETHE1,FAM173A,FBXO11,FKBP3,FXYD6,GNL3,GPS2,GSK3B,GSTM4,GTF2H1,HDAC1,HDAC2,HIF1A,HIPK1,HIPK2,HIPK3,HMGB1,HNF4A,HSP90AA1,HSPA4,HSPA8,HSPA9,HSPB1,HTT,Hipk1,IFI16,ING1,ING4,ING5,ITCH,KAT2B,KIAA0087,KPNB1,LAMA4,MAD2L1BP,MAGEB18,MAPK1,MAPK10,MAPK3,MAPK8,MAPK9,MDC1,MDM2,MDM4,MED1,MED17,MNAT1,MPHOSPH6,MTA1,MTA2,MYST2,Mapk1,NCL,NDN,NEDD8,NFKBIA,NQO2,NR3C1,NR4A1,NUMB,OTUD5,PADI4,PAFAH1B3,PARP1,PCDHA4,PHB,PIAS1,PIN1,PLAGL1,PLK3,PML,PNP,POLA1,PPA1,PPP1R13L,PPP4C,PRKDC,PRKRA,PRKRIR,PRMT1,PSMD11,PSME3,PTEN,PTGS2,PTK2,PTTG1,RAB4A,RAD51,RCHY1,RFC1,RFWD2,RPA1,RPL11,RRM2,RRM2B,RYBP,S100A4,S100A8,S100B,SAT1,SERPINB9,SERPINH1,SFN,SIZ1,SMARCA4,SMARCB1,SMARCC1,SMN1,SNRPN,SP1,STAT6,STK11,STUB1,STX5,SULT1E1,SUMO1,TADA3,TAF1,TAF1A,TAF1B,TAF1C,TAF6,TAF9,TAG,TBP,TDG,TEP1,TFAP2A,TFAP2C,TFDP1,THAP8,THRB,TK1,TOP1,TOP2A,TOP2B,TOPORS,TP53,TP53BP1,TP53BP2,TP53INP1,TP53RK,TSG101,TXN,Tmsb4x,UBC,UBE2A,UBE2I,UBE2N,UCHL1,USP11,USP39,USP7,VRK1,WDR33,WDR48,WRN,WT1,WWOX,XRCC1,YBX1,YWHAZ,ZCCHC10,ZMIZ1,ZMIZ2,ZMYND11,ZNF148,ZNF24
Protein Size: 393 -
Molecular Weight
- 44 kDa
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Gene ID
- 7157
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NCBI Accession
- NM_000546, NP_000537
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UniProt
- P04637
Target
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