Tripartite Motif Containing 21 (TRIM21) Peptide
TRIM21
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN985494
Quick Overview for Tripartite Motif Containing 21 (TRIM21) Peptide (ABIN985494)
Target
TRIM21
(Tripartite Motif Containing 21 (TRIM21))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TRIM21 antibody (Catalog #: ARP38248_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TRIM21 (Tripartite Motif Containing 21 (TRIM21))
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Background
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TRIM21 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. TRIM21 is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus.This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: RNF81, RO52, SSA, SSA1
Protein Interaction Partner: NIF3L1,TRIM21,TROVE2,USP4,YWHAZ,CUL1,IRF8,NCOA1,NCOA3,NIF3L1,SKP1,SKP2,TRIM21,UBC,USP19,USP4
Protein Size: 475 -
Molecular Weight
- 54 kDa
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Gene ID
- 6737
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NCBI Accession
- NM_003141, NP_003132
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UniProt
- P19474
Target
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