Ubiquitin Specific Peptidase 10 (USP10) (C-Term) Peptide
USP10
Reactivity: Rat
Host: Synthetic
BP, WB
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- Target See all USP10 products
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
- Protein Region
- C-Term
- Origin
- Rat
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RDIRPGAAFE PTYIYRLLTV IKSSLSEKGR QEDAEEYLGF ILNGLHEEML
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Usp10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- USP10 (Ubiquitin Specific Peptidase 10 (USP10))
- Background
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Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Alias Symbols: MGC124997
Protein Size: 794 - Molecular Weight
- 87 kDa
- Gene ID
- 307905
- NCBI Accession
- NM_001034146, NP_001029318
- UniProt
- Q3KR59
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