Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Middle Region) Peptide
ZCCHC11
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN986381
Quick Overview for Zinc Finger, CCHC Domain Containing 11 (ZCCHC11) (Middle Region) Peptide (ABIN986381)
Target
ZCCHC11
(Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- GSAQQQGDQS IRTRQSSECS ESPSYSPQPQ PFPQNSSQSA AITQPSSQPG
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-ZCCHC11 Antibody(ARP58745_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ZCCHC11 (Zinc Finger, CCHC Domain Containing 11 (ZCCHC11))
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Background
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ZCCHC11 is the uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. ZCCHC11 catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency.ZCCHC11 does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. ZCCHC11 also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression.ZCCHC11 may also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. ZCCHC11 does not play a role in replication-dependent histone mRNA degradation.
Alias Symbols: PAPD3, TUT4
Protein Size: 1645 -
Molecular Weight
- 185 kDa
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Gene ID
- 23318
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NCBI Accession
- NM_001009881, NP_001009881
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UniProt
- Q5TAX3
Target
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