(3 references)
Catalog No. ABIN987295
Quick Overview for Amyloid beta (Abeta) (AA 1-42) Peptide (ABIN987295)
Target
beta Amyloid (Abeta)
(Amyloid beta (Abeta))
Origin
Human
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Protein Region
- AA 1-42
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Sequence
- One-letter code: DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IADocument s HPLC: 20060721145613 (PDF) MS: 20060721145553 (PDF) MSDS: 20080923043843 (PDF) COA: RP10017_78425001022710XB (PDF) COA: RP10017_78425001091009XB (PDF) TECHNICAL MANUAL: 20100407015038 (PDF) COA: RP10017_86847001020310WY (PDF) Figures zoo, Three-letter code: {ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}{GLY}{SER} {ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL}{ILE}{ALA
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Characteristics
- Formula: C203H311N55O60S1
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Purity
- > 95 %
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Comment
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This product is a chemically-modified β-amyloid (1-42) precursor, which belongs to "click peptides". The "click peptides" are best described by the following key features: 1. Enhanced Stability—The O-acyl moiety within the click peptide is stable even under acidic pH. 2. Convenient and quick process—The "click peptides" can be easily converted to native peptide at pH 7.4 or above. 3. No by-product formation in the conversion process. 4. High Solubility—15 mg/ml for click peptide in water compared to 0.14 mg/ml for the native peptide. 5. Superior quality—After the "click", the aggregative property of the peptides is significantly minimized compared to its native format.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- -20 °C
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: "Dual ligand immunoliposomes for drug delivery to the brain." in: Colloids and surfaces. B, Biointerfaces, Vol. 134, pp. 213-9, (2015) (PubMed).
: "Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-A? antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution." in: PLoS ONE, Vol. 9, Issue 7, pp. e101474, (2014) (PubMed).
: "Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease." in: PLoS ONE, Vol. 7, Issue 3, pp. e32616, (2012) (PubMed).
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: "Dual ligand immunoliposomes for drug delivery to the brain." in: Colloids and surfaces. B, Biointerfaces, Vol. 134, pp. 213-9, (2015) (PubMed).
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- beta Amyloid (Abeta) (Amyloid beta (Abeta))
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Background
- This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the longer forms of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors. Solubility: Insoluble in water, may be dissolved in any buffer with pH greater than 915 mg/ml for click peptide in water compared to 0.14 mg/ml for the native peptide.
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Molecular Weight
- 4514.1
Target
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