Browse our anti-AKT2 (AKT2) Antibodies

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. AKT1 (show AKT1 Antibodies) and AKT2 isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.

2. IRF5 (show IRF5 Antibodies) and IRF5 (show IRF5 Antibodies) disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation.

3. Deficiency of AKT2 in myocardium results in diminished MEF2A (show MEF2A Antibodies) abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG (show ENDOG Antibodies), which is also regulated by AKT2, is a suppressor of MEF2A (show MEF2A Antibodies) in myocardium.

4. Results indicate that AKT2 modulates pulmonary fibrosis through inducing TGF-beta1 (show TGFB1 Antibodies) and IL-13 (show IL13 Antibodies) production by macrophages, and inhibition of AKT2 may be a potential strategy for treating Idiopathic pulmonary fibrosis.

5. Sirt1 (show SIRT1 Antibodies) significantly reduced the levels of raptor (show RPTOR Antibodies) and inactivated mammalian target of rapamycin (mTOR (show FRAP1 Antibodies))C1 signal by interacting with Akt2.

6. This review summarises and discusses the consequences of genetic deletions of Akt (show AKT1 Antibodies) isoforms in adult mice and their implications for cancer therapy. Whereas combined Akt1 (show AKT1 Antibodies) and Akt2 rapidly induced mortality, hepatic Akt (show AKT1 Antibodies) inhibition induced liver injury that promotes hepatocellular carcinoma.

7. Rac1 activation is caused by membrane translocation of a guanine nucleotide exchange factor (show ARHGEF12 Antibodies) FLJ00068 in Akt2-mediated insulin (show INS Antibodies) signaling in mouse skeletal muscle.

8. BAY 1125976 is a potent and highly selective allosteric AKT1 (show AKT1 Antibodies)/2 inhibitor.

9. AKT2 inhibition induces a unique mitochondrial-dependent DNA degradation pathway by activating nucleus translocation of AIF (show AIFM1 Antibodies) and EndoG (show ENDOG Antibodies) during cardiac ischemia.

10. Akt2 ablation may protect against paraquat toxicity-induced cardiac contractile defect and apoptosis possibly via regulation of Nrf2 (show NFE2L2 Antibodies) activation and mitochondrial homeostasis.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. miR296 is downregulated in tissue from patients with pancreatic cancer and pancreatic carcinoma cell lines. These findings suggested that it may function as a tumor suppressor via inhibiting the growth, migration and invasion of pancreatic cancer cells. AKT2 was validated as a direct target of miR296 in pancreatic cancer cells.

2. miR (show MLXIP Antibodies)-143-3p acts as a novel tumor suppressive miRNA by regulating gastric tumor growth, migration and invasion through directly targeting AKT2 gene

3. Our findings suggest that Akt2 might be associated with the resistance to anti-EGFR (show EGFR Antibodies) therapies, especially the use of erlotinib against PC, and that this resistance can be overcome by combined treatment with a PI3K (show PIK3CA Antibodies) inhibitor. Akt2 expression could become a predictive biomarker for erlotinib resistance in PC.

4. Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 activation requires EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies) activity, whereas migration and invasion are dependent on FFAR4 (show O3FAR1 Antibodies), EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) activity.

5. Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (show CCNE1 Antibodies) and AKT2 Overexpression of Cyclin E1 (show CCNE1 Antibodies) and AKT (show AKT1 Antibodies) isoforms, in addition to mutant TP53 (show TP53 Antibodies), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer

6. Akt1 (show AKT1 Antibodies)-Akt3 (show AKT3 Antibodies) activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.

7. Recent studies reveal that AKT2-NOX2 (show CYBB Antibodies) signaling has critical roles in Ca mobilization, ROS (show ROS1 Antibodies) generation, degranulation, and control of the ligand-binding function of cell surface molecules, thereby promoting heterotypic cell-cell interactions in thromboinflammation.

8. The expression levels of AKT2 and CDC25C (show CDC25C Antibodies) showed lower expression in neural tube defects. And the percentage of methylated region of AKT2 promoter were increased in neural tube defects.

9. AKT1 (show AKT1 Antibodies) and AKT2 isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.

10. Report frequency of genetic variation in Akt2 and discuss link to type 2 diabetes.

Zebrafish V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis.

2. Study reports that Appl1 (show APPL1 Antibodies) regulates the activity of Akt (show AKT1 Antibodies) and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.

3. EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.

4. akt2 has a role in an integrative pathway directly linking glucose, Glut1 (show SLC2A1 Antibodies) expression, and activation of apoptosis

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. Profilin (show PFN1 Antibodies)-dependent dissociation of G-actin (show ACTB Antibodies)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK (show ILK Antibodies)) in the lamellipodia.