Browse our anti-AKT2 (AKT2) Antibodies

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. The authors find in Mus (show TRPV6 Antibodies) musculus, each AKT (show AKT1 Antibodies) isoform has a unique expression pattern in the hippocampus. AKT1 (show AKT1 Antibodies), but not AKT2 or AKT3 (show AKT3 Antibodies), is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT (show AKT1 Antibodies) activity inhibits mGluR (show GRM8 Antibodies)-LTD, with overlapping functions for AKT1 (show AKT1 Antibodies) and AKT3 (show AKT3 Antibodies).

2. At 3days after the first tamoxifen injection, Akt1 (show AKT1 Antibodies)(-/-)/iAkt2 KO hearts showed decreased expression of connexin43 (Cx43 (show GJA1 Antibodies)) and connexin-interacting protein zonula occludens-1 (ZO-1 (show TJP1 Antibodies)). Furthermore, Akt1 (show AKT1 Antibodies)/2 silencing significantly decreased both Cx43 (show GJA1 Antibodies) and ZO-1 (show TJP1 Antibodies) expression

3. Data (including data from studies in transgenic and mutant mice) suggest that Akt2 plays critical role in type 1 diabetes in metallothionein (show MT Antibodies)-mediated preservation of cardiac insulin (show INS Antibodies)-stimulated metabolic signaling (insulin (show INS Antibodies) resistance) and preservation of cardiac function; this mechanism appear to involve inhibition of cardiac Trb3 (show TRIB3 Antibodies). (Akt2 = protein kinase Akt-2; Trb3 (show TRIB3 Antibodies) = tribbles (show TRIB1 Antibodies) pseudokinase 3)

4. The data indicate that Akt2 ablation protects against cardiac aging through restored Foxo1 (show FOXO1 Antibodies)-related autophagy and mitochondrial integrity.

5. AKT1 (show AKT1 Antibodies) and AKT2 isoforms have opposing roles in smooth muscle cell proliferation, migration, differentiation, and rapamycin response in vitro and in vascular injury in vivo.

6. IRF5 (show IRF5 Antibodies) and IRF5 (show IRF5 Antibodies) disease-risk variants increase glycolysis and human m1 macrophage polarization by regulating proximal signaling and Akt2 activation.

7. Deficiency of AKT2 in myocardium results in diminished MEF2A (show MEF2A Antibodies) abundance, which induced decreased size of cardiomyocytes. We additionally confirmed that EndoG (show ENDOG Antibodies), which is also regulated by AKT2, is a suppressor of MEF2A (show MEF2A Antibodies) in myocardium.

8. Results indicate that AKT2 modulates pulmonary fibrosis through inducing TGF-beta1 (show TGFB1 Antibodies) and IL-13 (show IL13 Antibodies) production by macrophages, and inhibition of AKT2 may be a potential strategy for treating Idiopathic pulmonary fibrosis.

9. Sirt1 (show SIRT1 Antibodies) significantly reduced the levels of raptor (show RPTOR Antibodies) and inactivated mammalian target of rapamycin (mTOR (show FRAP1 Antibodies))C1 signal by interacting with Akt2.

10. This review summarises and discusses the consequences of genetic deletions of Akt (show AKT1 Antibodies) isoforms in adult mice and their implications for cancer therapy. Whereas combined Akt1 (show AKT1 Antibodies) and Akt2 rapidly induced mortality, hepatic Akt (show AKT1 Antibodies) inhibition induced liver injury that promotes hepatocellular carcinoma.

Human V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. Data found that S131 of Akt2 is not phosphorylated by CK2 (show CSNK2A1 Antibodies) although the consensus sequence recognized by CK2 (show CSNK2A1 Antibodies) (S/T-x-x-E/D/pS/pT) is conserved. A single sequence element, a T at position n+1, hampers phosphorylation, causing an alpha-helix structure preventing the recognition of its own consensus by CK2 (show CSNK2A1 Antibodies). Using synthetic peptides, study suggests that Akt2 S131 could be phosphorylated by kinases of the Plk (show PLK1 Antibodies) family.

2. Findings demonstrate that DSBs trigger pro-survival autophagy in an ATM (show ATM Antibodies)- and p53 (show TP53 Antibodies)-dependent manner, which is curtailed by AKT2 signaling.

3. genetic association studies in population of men in Finland: Data suggest that a partial loss-of-function variant in AKT2 (p.Pro50Thr) is associated with type 2 diabetes in the population studied; this AKT2 variant is associated with reduced insulin (show INS Antibodies)-mediated glucose uptake in multiple insulin (show INS Antibodies)-sensitive tissues.

4. miR2965p/AKT2 axis serves important roles in Hepatocellular carcinoma carcinogenesis and progression.

5. miR296 is downregulated in tissue from patients with pancreatic cancer and pancreatic carcinoma cell lines. These findings suggested that it may function as a tumor suppressor via inhibiting the growth, migration and invasion of pancreatic cancer cells. AKT2 was validated as a direct target of miR296 in pancreatic cancer cells.

6. miR (show MLXIP Antibodies)-143-3p acts as a novel tumor suppressive miRNA by regulating gastric tumor growth, migration and invasion through directly targeting AKT2 gene

7. Our findings suggest that Akt2 might be associated with the resistance to anti-EGFR (show EGFR Antibodies) therapies, especially the use of erlotinib against PC, and that this resistance can be overcome by combined treatment with a PI3K (show PIK3CA Antibodies) inhibitor. Akt2 expression could become a predictive biomarker for erlotinib resistance in PC.

8. Studied action of linoleic acid (LA) on cell migration and neoplasm invasiveness of breast cancer cells. Findings show Akt2 activation requires EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies) activity, whereas migration and invasion are dependent on FFAR4 (show O3FAR1 Antibodies), EGFR (show EGFR Antibodies) and PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) activity.

9. Analysis of genomic data from TCGA demonstrated coamplification of CCNE1 (show CCNE1 Antibodies) and AKT2 Overexpression of Cyclin E1 (show CCNE1 Antibodies) and AKT (show AKT1 Antibodies) isoforms, in addition to mutant TP53 (show TP53 Antibodies), imparted malignant characteristics in untransformed fallopian tube secretory cells, the dominant site of origin of high-grade serous ovarian cancer

10. Akt1 (show AKT1 Antibodies)-Akt3 (show AKT3 Antibodies) activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.

Zebrafish V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis.

2. Study reports that Appl1 (show APPL1 Antibodies) regulates the activity of Akt (show AKT1 Antibodies) and, importantly, its downstream signaling specificity from an endosomal compartment, with profound implications for development.

3. EDN1 plays an important role in hepatocellular carcinoma progression by activating the PI3K/AKT pathway and is regulated by miR-1.

4. akt2 has a role in an integrative pathway directly linking glucose, Glut1 (show SLC2A1 Antibodies) expression, and activation of apoptosis

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) interaction partners

1. Profilin (show PFN1 Antibodies)-dependent dissociation of G-actin (show ACTB Antibodies)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK (show ILK Antibodies)) in the lamellipodia.