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AKT2 antibody

AKT2 Reactivity: Human, Rat, Monkey WB, ELISA, IHC, ICC Host: Mouse Monoclonal 1B6 unconjugated
Catalog No. ABIN1724720
  • Target See all AKT2 Antibodies
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    Reactivity
    • 186
    • 103
    • 67
    • 16
    • 14
    • 13
    • 13
    • 13
    • 11
    • 10
    • 10
    • 10
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Rat, Monkey
    Host
    • 166
    • 27
    • 5
    • 2
    • 1
    • 1
    Mouse
    Clonality
    • 167
    • 33
    Monoclonal
    Conjugate
    • 96
    • 17
    • 16
    • 11
    • 9
    • 9
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This AKT2 antibody is un-conjugated
    Application
    • 170
    • 108
    • 72
    • 38
    • 28
    • 27
    • 26
    • 19
    • 19
    • 10
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human AKT2 expressed in E. coli.
    Clone
    1B6
    Isotype
    IgG2b
    Top Product
    Discover our top product AKT2 Primary Antibody
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Gosmanov, Umpierrez, Karabell, Cuervo, Thomason: "Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes." in: American journal of physiology. Endocrinology and metabolism, Vol. 287, Issue 1, pp. E8-E15, (2004) (PubMed).

    Xu, Sakon, Nagano, Hiraoka, Yamamoto, Hayashi, Dono, Nakamori, Umeshita, Ito, Matsuura, Monden: "Akt2 expression correlates with prognosis of human hepatocellular carcinoma." in: Oncology reports, Vol. 11, Issue 1, pp. 25-32, (2003) (PubMed).

  • Target
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    Alternative Name
    AKT2 (AKT2 Products)
    Synonyms
    AKT2 antibody, pkbb antibody, pkbbeta antibody, pkbss antibody, prkbb antibody, rac-beta antibody, v-akt2 antibody, 2410016A19Rik antibody, AW554154 antibody, PKB antibody, PKBbeta antibody, HIHGHH antibody, PKBB antibody, PKBBETA antibody, PRKBB antibody, RAC-BETA antibody, cb945 antibody, akt2-a antibody, AKT serine/threonine kinase 2 antibody, v-akt murine thymoma viral oncogene homolog 2 antibody, thymoma viral proto-oncogene 2 antibody, v-akt murine thymoma viral oncogene homolog 2 L homeolog antibody, AKT2 antibody, akt2 antibody, Akt2 antibody, akt2.L antibody
    Background

    Description: Akt2 (also designated protein kinase B beta or v-akt murine thymoma viral oncogene homolog 2 ), with 481-amino acid protein (about 53 kDa), belongs to the AKT serine/threonine protein kinase family, which also includes Akt1 and Akt3. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Among the members of AKT family, Akt2 is associated with the development of human cancers. Akt2 inhibits cisplatin-induced JNK/p38 and Bax activation through phosphorylation of ASK1 and thus, plays an important role in chemoresistance. Further, Akt2 plays a specific role in muscle differentiation.

    Aliases: PKBB, PRKBB, PKBBETA, RAC-BETA

    Molecular Weight
    60 kDa
    Gene ID
    208
    HGNC
    208
    Pathways
    PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, TLR Signaling, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling
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