Browse our anti-AKT3 (AKT3) Antibodies

Human V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) interaction partners

1. Akt3 isoform expression in triple negative breast cancer.AKT3 splice variant lacking serine-472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis.

2. FEZF1 (show FEZF1 Antibodies)-AS1 (show PTGDR Antibodies) promoted multiple myeloma cells proliferation through regulating miR (show MLXIP Antibodies)-610/Akt3 axis.

3. these results suggested that this newly identified miR497/AKT3 signaling pathway may contribute to papillary thyroid cancer (PTC (show F9 Antibodies))occurrence and progression. These findings provide novel potential therapeutic targets for the therapy of PTC (show F9 Antibodies)

4. miR (show MLXIP Antibodies)-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of Lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD

5. these findings illustrated that cir (show KCNJ5 Antibodies)-ZNF609 (show ZNF609 Antibodies) took part in the onset of HSCR (show EDNRB Antibodies) through the crosstalk with AKT3 by competing for shared miR (show MLXIP Antibodies)-150-5p.

6. Results found that TR4 (show NR2C2 Antibodies) promotes the AKT3 expression through transcriptional regulation to drive the EMT (show ITK Antibodies) phenotype and enhance the seminoma cell proliferation and invasion.

7. Akt1 (show AKT1 Antibodies)-Akt3 activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.

8. The results of this study indicated AKT (show AKT1 Antibodies) isoforms have different roles and downstream substrates in glioblastoma. and they indicate AKT3 delays tumor progression.

9. Report frequency of genetic variation in Akt3 and discuss link to disease.

10. AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.

Mouse (Murine) V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) interaction partners

1. The authors find in Mus (show TRPV6 Antibodies) musculus, each AKT (show AKT1 Antibodies) isoform has a unique expression pattern in the hippocampus. AKT1 (show AKT1 Antibodies), but not AKT2 (show AKT2 Antibodies) or AKT3, is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT (show AKT1 Antibodies) activity inhibits mGluR (show GRM8 Antibodies)-LTD, with overlapping functions for AKT1 (show AKT1 Antibodies) and AKT3.

2. Behavioral data on Akt3-/- and Akt1 (show AKT1 Antibodies)-/- mice demonstrated that Akt3 but not Akt1 (show AKT1 Antibodies) is required for spatial learning. Histological analyses on synapse, dendrite, and myelin markers suggested that Akt3 but not Akt1 (show AKT1 Antibodies) is important for the white matter integrity, and that Akt (show AKT1 Antibodies) single isoform does not play a pivotal role on neuronal survival.

3. Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.

4. findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling in brain

5. these results indicate that PI3K and Akt ( Akt1 (show AKT1 Antibodies)-Akt3)play distinct roles, and that PI3K stimulates Akt (show AKT1 Antibodies)-independent pathways that are important for GLUT4 (show SLC2A4 Antibodies) translocation.

6. miR (show MLXIP Antibodies)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.

7. Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Antibodies)/SGK1 (show SGK1 Antibodies)/Cdc42 (show CDC42 Antibodies) pathway.

8. The predominant AKT (show AKT1 Antibodies) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (show AKT1 Antibodies) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Antibodies)-induced axon regeneration.

9. Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (show S100A4 Antibodies).

10. In viable Akt (show AKT1 Antibodies) three-isoforms conditional knockout mice, total Akt (show AKT1 Antibodies) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.

Cow (Bovine) V-Akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) (AKT3) interaction partners

1. Comparative Analysis of V-Akt (show AKT1 Antibodies) Murine Thymoma Viral Oncogene (show RAB1A Antibodies) Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis.

2. These findings are important because Wnt (show WNT2 Antibodies), BMPR2 (show BMPR2 Antibodies), and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.