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anti-Human AKT3 Antibodies:
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Human Polyclonal AKT3 Primary Antibody for DB - ABIN389853
Huang, Gonzalez, Toy, Banerjee, Kleer: Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. in Cancer research 2010
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Human Polyclonal AKT3 Primary Antibody for ICC, IF - ABIN4279075
Vredeveld, Possik, Smit, Meissl, Michaloglou, Horlings, Ajouaou, Kortman, Dankort, McMahon, Mooi, Peeper: Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. in Genes & development 2012
Show all 3 Pubmed References
Human Monoclonal AKT3 Primary Antibody for ELISA, WB - ABIN968952
Easton, Cho, Roovers, Shineman, Mizrahi, Forman, Lee, Szabolcs, de Jong, Oltersdorf, Ludwig, Efstratiadis, Birnbaum: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. in Molecular and cellular biology 2005
Show all 2 Pubmed References
Human Monoclonal AKT3 Primary Antibody for ELISA, WB - ABIN965532
Stahl, Sharma, Cheung, Zimmerman, Cheng, Bosenberg, Kester, Sandirasegarane, Robertson: Deregulated Akt3 activity promotes development of malignant melanoma. in Cancer research 2004
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Human Monoclonal AKT3 Primary Antibody for FACS, IF - ABIN2715859
Veillette, Grenier, Brasseur, Fréchette-Frigon, Leblanc, Parent, Asselin: Regulation of the PI3-K/Akt survival pathway in the rat endometrium. in Biology of reproduction 2013
Human Polyclonal AKT3 Primary Antibody for ELISA, WB - ABIN250324
Zinda, Johnson, Paul, Horn, Konicek, Lu, Sandusky, Thomas, Neubauer, Lai, Graff: AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. in Clinical cancer research : an official journal of the American Association for Cancer Research 2001
Human Monoclonal AKT3 Primary Antibody for IHC, ELISA - ABIN1043749
Bogen, Jensen, Hvalby, Walaas: Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. in Seminars in cell & developmental biology 2011
these results suggested that this newly identified miR497/AKT3 signaling pathway may contribute to papillary thyroid cancer (PTC (show F9 Antibodies))occurrence and progression. These findings provide novel potential therapeutic targets for the therapy of PTC (show F9 Antibodies)
miR (show MLXIP Antibodies)-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of Lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD
these findings illustrated that cir (show KCNJ5 Antibodies)-ZNF609 (show ZNF609 Antibodies) took part in the onset of HSCR (show EDNRB Antibodies) through the crosstalk with AKT3 by competing for shared miR (show MLXIP Antibodies)-150-5p.
Results found that TR4 (show NR2C2 Antibodies) promotes the AKT3 expression through transcriptional regulation to drive the EMT (show ITK Antibodies) phenotype and enhance the seminoma cell proliferation and invasion.
Akt1 (show AKT1 Antibodies)-Akt3 activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.
The results of this study indicated AKT (show AKT1 Antibodies) isoforms have different roles and downstream substrates in glioblastoma. and they indicate AKT3 delays tumor progression.
Report frequency of genetic variation in Akt3 and discuss link to disease.
AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.
Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.
High AKT3 expression is associated with triple-negative breast cancer.
The authors find in Mus (show TRPV6 Antibodies) musculus, each AKT (show AKT1 Antibodies) isoform has a unique expression pattern in the hippocampus. AKT1 (show AKT1 Antibodies), but not AKT2 (show AKT2 Antibodies) or AKT3, is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT (show AKT1 Antibodies) activity inhibits mGluR (show GRM8 Antibodies)-LTD, with overlapping functions for AKT1 (show AKT1 Antibodies) and AKT3.
Behavioral data on Akt3-/- and Akt1 (show AKT1 Antibodies)-/- mice demonstrated that Akt3 but not Akt1 (show AKT1 Antibodies) is required for spatial learning. Histological analyses on synapse, dendrite, and myelin markers suggested that Akt3 but not Akt1 (show AKT1 Antibodies) is important for the white matter integrity, and that Akt (show AKT1 Antibodies) single isoform does not play a pivotal role on neuronal survival.
findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) signaling in brain
these results indicate that PI3K and Akt ( Akt1 (show AKT1 Antibodies)-Akt3)play distinct roles, and that PI3K stimulates Akt (show AKT1 Antibodies)-independent pathways that are important for GLUT4 (show SLC2A4 Antibodies) translocation.
miR (show MLXIP Antibodies)-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Antibodies)/SGK1 (show SGK1 Antibodies)/Cdc42 (show CDC42 Antibodies) pathway.
The predominant AKT (show AKT1 Antibodies) isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 (show AKT1 Antibodies) and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT (show AKT1 Antibodies)-induced axon regeneration.
Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4 (show S100A4 Antibodies).
In viable Akt (show AKT1 Antibodies) three-isoforms conditional knockout mice, total Akt (show AKT1 Antibodies) levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.
These findings are important because Wnt (show WNT2 Antibodies), BMPR2 (show BMPR2 Antibodies), and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
, RAC-gamma serine/threonine protein kinase
, RAC-gamma serine/threonine-protein kinase
, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
, protein kinase Akt-3
, protein kinase B gamma
, AKT3 kinase
, protein kinase B, gamma
, thymoma viral proto-oncogene 3
, v-akt murine thymoma viral oncogene 3
, protein kinase B gamma-like protein
, v-akt murine thymoma viral oncogene-like 3
, LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase