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anti-Human AKT3 Antibodies:
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Human Polyclonal AKT3 Primary Antibody for DB - ABIN389853
Huang, Gonzalez, Toy, Banerjee, Kleer: Blockade of CCN6 (WISP3) activates growth factor-independent survival and resistance to anoikis in human mammary epithelial cells. in Cancer research 2010
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Human Polyclonal AKT3 Primary Antibody for ELISA, WB - ABIN545477
Brozinick, Roberts, Dohm: Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance. in Diabetes 2003
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Human Polyclonal AKT3 Primary Antibody for DB, ELISA - ABIN548679
Tiwari, Sakaue, Pollack, Roth: Gene expression profiling in prostate cancer cells with Akt activation reveals Fra-1 as an Akt-inducible gene. in Molecular cancer research : MCR 2003
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Human Polyclonal AKT3 Primary Antibody for ICC, IF - ABIN4279075
Vredeveld, Possik, Smit, Meissl, Michaloglou, Horlings, Ajouaou, Kortman, Dankort, McMahon, Mooi, Peeper: Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. in Genes & development 2012
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Human Monoclonal AKT3 Primary Antibody for ELISA, WB - ABIN965532
Easton, Cho, Roovers, Shineman, Mizrahi, Forman, Lee, Szabolcs, de Jong, Oltersdorf, Ludwig, Efstratiadis, Birnbaum: Role for Akt3/protein kinase Bgamma in attainment of normal brain size. in Molecular and cellular biology 2005
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Human Monoclonal AKT3 Primary Antibody for ELISA, WB - ABIN968952
Stahl, Sharma, Cheung, Zimmerman, Cheng, Bosenberg, Kester, Sandirasegarane, Robertson: Deregulated Akt3 activity promotes development of malignant melanoma. in Cancer research 2004
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Human Monoclonal AKT3 Primary Antibody for IHC, ELISA - ABIN1043749
Bogen, Jensen, Hvalby, Walaas: Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse. in Seminars in cell & developmental biology 2011
Human Polyclonal AKT3 Primary Antibody for ELISA, WB - ABIN547367
Zinda, Johnson, Paul, Horn, Konicek, Lu, Sandusky, Thomas, Neubauer, Lai, Graff: AKT-1, -2, and -3 are expressed in both normal and tumor tissues of the lung, breast, prostate, and colon. in Clinical cancer research : an official journal of the American Association for Cancer Research 2001
Human Monoclonal AKT3 Primary Antibody for FACS, IF - ABIN2715859
Veillette, Grenier, Brasseur, Fréchette-Frigon, Leblanc, Parent, Asselin: Regulation of the PI3-K/Akt survival pathway in the rat endometrium. in Biology of reproduction 2013
The authors have found that overexpression of RIZ1 in HEK293 cells reduced the expression of Akt3 protein.
Akt3 isoform expression in triple negative breast cancer.AKT3 splice variant lacking serine-472 phosphorylation site promotes apoptosis and suppresses mammary tumorigenesis.
FEZF1-AS1 promoted multiple myeloma cells proliferation through regulating miR-610/Akt3 axis.
these results suggested that this newly identified miR497/AKT3 signaling pathway may contribute to papillary thyroid cancer (PTC)occurrence and progression. These findings provide novel potential therapeutic targets for the therapy of PTC
miR-30a-3p may be a promising biomarker for the early screening of high-risk populations and early diagnosis of Lung adenocarcinoma (LUAD). Our studies provide insights into identifying novel potential biomarkers for diagnosis and prognosis of LUAD
these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
Results found that TR4 promotes the AKT3 expression through transcriptional regulation to drive the EMT phenotype and enhance the seminoma cell proliferation and invasion.
Akt1-Akt3 activity (according to Thr308 phosphorylation) is not associated with proliferative processes in the tumor tissue of the thyroid.
The results of this study indicated AKT isoforms have different roles and downstream substrates in glioblastoma. and they indicate AKT3 delays tumor progression.
Report frequency of genetic variation in Akt3 and discuss link to disease.
AKT3 Splice Variants are associated with HPV-Positive Oropharyngeal Cancers.
Results show that AKT3 influences outcome of pneumococcal meningitis in human patients; validated the findings in a mouse experimental pneumococcal meningitis model.
High AKT3 expression is associated with triple-negative breast cancer.
This study showed that activating mutations of AKT3 are associated with a much broader spectrum of developmental brain disorders in children, with several clinical phenotypes determined partially by the type of mutation and level of mosaicism.
MiR-511-3p may serve as a prognostic factor and tumor suppressor in prostate cancer, very likely through inverse regulation of its downstream target gene of AKT3.
Studies found AKT3 to be important in coordinating mitochondrial biogenesis with growth factor-induced increase in cellular energy demands. This isoform also plays an important role in platelet activation and thrombosis. [review]
miR-29b prevents angiogenesis/tumorigenesis in breast cancer cell by targeting Akt3 and inducing VEGF and C-myc arrest in breast cancer cells.
AKT3 expression is markedly upregulated in AKT inhibitor-resistant cells. Induction of AKT3 is regulated epigenetically by the bromodomain and extra terminal domain proteins. Importantly, knockdown of AKT3, but not AKT1 or AKT2, in resistant cells restores sensitivity to MK2206.
miR-15b-5p is a critical regulator of human EC proliferation and migration by targeting the AKT3 pathway.
Akt3 constitutively suppresses macropinocytosis in macrophages through a novel WNK1/SGK1/Cdc42 pathway.
The authors find in Mus musculus, each AKT isoform has a unique expression pattern in the hippocampus. AKT1, but not AKT2 or AKT3, is required for late long term potetiation (LTD) through regulating activity-induced protein synthesis. Interestingly, AKT activity inhibits mGluR-LTD, with overlapping functions for AKT1 and AKT3.
Behavioral data on Akt3-/- and Akt1-/- mice demonstrated that Akt3 but not Akt1 is required for spatial learning. Histological analyses on synapse, dendrite, and myelin markers suggested that Akt3 but not Akt1 is important for the white matter integrity, and that Akt single isoform does not play a pivotal role on neuronal survival.
findings provide novel insight into the neurodevelopmental role of Akt3, identify a non-redundant role for Akt3 in the development of prefrontal cortical-mediated cognitive function and show that Akt3 is potentially the dominant regulator of AKT/mTOR signaling in brain
these results indicate that PI3K and Akt ( Akt1-Akt3)play distinct roles, and that PI3K stimulates Akt-independent pathways that are important for GLUT4 translocation.
The predominant AKT isoform in the central nervous system, AKT3, induces much more robust axon regeneration than AKT1 and that activation of mTORC1 and inhibition of GSK3beta are two critical parallel pathways for AKT-induced axon regeneration.
Downregulation of AKT3 increases migration and metastasis in triple negative breast cancer cells by upregulating S100A4.
In viable Akt three-isoforms conditional knockout mice, total Akt levels were reduced in the adult brain. They had increased levels of phosphorylated tau, GSK3alpha and PKA substrates. No significant changes in p-tau levels were found in Akt3-/-)mice.
untreated Akt1 and Akt2/Akt3 double knockout mice display significant hearing loss, indicating a role for these isoforms in normal hearing.
MicroRNA-207 enhances radiation-induced apoptosis by targeting Akt3 in cochlea hair cells.
Blocking Akt1 or Akt3 but not Akt2 expression prohibits cell proliferation and reprogramming.
Mechanistic investigations uncovered opposing functions for different Akt isoforms in this regulation, where Akt1 promotes and Akt3 inhibits vascular tumor growth.
MiR-29 modulates growth and promotes differentiation of skeletal muscle through the post-transcriptional downregulation of Akt3.
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1.
Findings demonstrate that N-cadherin suppresses Akt3 to promote cell motility and highlight the intricate regulation of Akt isoforms by N-cadherin during metastasis.
AKT3-deficient mice have a more severe disease course than wild-type mice during experimental autoimmune encephalomyelitis (EAE), because AKT3 is necessary for proper central nervous system (CNS) cell integrity.
Results demonstrate that integrin outside-in signaling and platelet spreading requires Src family kinase-dependent and ADP receptor-amplified activation of the PI3K-Akt-GSK-3beta pathway.
nonredundant atheroprotective role for Akt3 exerted via the previously unknown link between the Akt signaling pathway and cholesterol metabolism.
Comparative Analysis of V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) Gene between Cow and Buffalo Reveals Substantial Differences for Mastitis.
These findings are important because Wnt, BMPR2, and Akt3 promote neurogenesis and cell survival, processes crucial for lifelong viral latency.
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
, RAC-gamma serine/threonine protein kinase
, RAC-gamma serine/threonine-protein kinase
, v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
, protein kinase Akt-3
, protein kinase B gamma
, AKT3 kinase
, protein kinase B, gamma
, thymoma viral proto-oncogene 3
, v-akt murine thymoma viral oncogene 3
, protein kinase B gamma-like protein
, v-akt murine thymoma viral oncogene-like 3
, LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase