Browse our anti-CDK2 (CDK2) Antibodies

Human Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. Proteomics and phosphoproteomics analyses identified CDK2 as a driver of resistance to both BRAF (show BRAF Antibodies) and Hsp90 (show HSP90 Antibodies) inhibitors and its expression is regulated by the transcription factor MITF (show MITF Antibodies) upon XL888 treatment of melanoma cells.

2. identified a new phosphorylation-based substrate recognition mechanism of PTPN12 (show PTPN12 Antibodies) by CDK2, which orchestrated signaling crosstalk between the oncogenic CDK2 and HER2 (show ERBB2 Antibodies) pathways

3. CDK2 gene is a strong candidate gene for type-2 diabetes. CDK2 gene is located in a risk area composed of 4 blocks in strong LD around the type-2 diabetes SNP rs2069408. CDK2 overexpression inhibits the association of insulin receptor (show INSR Antibodies) to the microtubule components, tubulin (show TUBB Antibodies) alpha and tubulin beta (show TUBB Antibodies). Physical association of the insulin receptor (show INSR Antibodies) complex with CDK2 is inhibited by the expression of tyrosine phosphatase PTPLAD1 (show PTPLAD1 Antibodies).

4. ATM and CDK2 control the chromatin remodeling activity of CSB in the regulation of double strand break repair pathway choice.

5. Among these genes, STAT3 (show STAT3 Antibodies) and CDK2 were significantly associated with recurrence. Further study suggested that inhibition of CDK2 reduced invasion of Pca (show FLVCR1 Antibodies) cell lines. The invasion ability was rescued after reintroduction of CDK2.

6. The roles of the CDK2/SIRT5 (show SIRT5 Antibodies) axis in gastric cancer.

7. CDK2 may have key functions in neuroblastoma (show ARHGEF16 Antibodies) progression by regulating the expression of neoplastic genes.

8. The authors show that human Cyclin (show PCNA Antibodies)-Dependent-Kinases (CDKs) target the RAD9 (show RAD9A Antibodies) subunit of the 9-1-1 checkpoint clamp (show PDZK1 Antibodies) on Thr292, to modulate DNA damage checkpoint activation. Thr292 phosphorylation on RAD9 (show RAD9A Antibodies) creates a binding site for Polo-Like-Kinase1 (PLK1), which phosphorylates RAD9 (show RAD9A Antibodies) on Thr313.

9. this study suggests that CDK2 and CDK9 (show CDK9 Antibodies) are potential therapeutic targets in Neuroblastoma (show ARHGEF16 Antibodies) (NB) and that abrogating CDK2 and CDK9 (show CDK9 Antibodies) activity by small molecules like dinaciclib is a promising strategy and a treatment option for NB patients

10. LINC00958 acts as an oncogenic gene in the gliomagenesis through miR (show MLXIP Antibodies)-203-CDK2 regulation, providing a novel insight into glioma tumorigenesis.

Xenopus laevis Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. evidence that cyclin A1 (show CCNA1 Antibodies)-associated activity is a mediator of apoptosis and that cyclin A1 (show CCNA1 Antibodies)/Cdk2 is sufficient to induce apoptosis

Mouse (Murine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. study suggests that hepatocellular carcinoma initiation specifically depends on CcnE1 (show CCNE1 Antibodies) and Cdk2, while HCC (show FAM126A Antibodies) progression requires expression of any E-cyclin (show PCNA Antibodies), but no Cdk2.

2. Identified a telomere localization domain on Speedy A covering the distal N terminus and the Cdk2-binding Ringo domain, and this domain is essential for the localization of Speedy A to telomeres.

3. CDK2 phosphorylates polyQ-AR specifically at Ser (show SIGLEC1 Antibodies)(96). Phosphorylation of polyQ-AR by CDK2 increased protein stabilization and toxicity and is negatively regulated by the adenylyl cyclase/protein kinase A signaling pathway in spinobulbar muscular atrophy.

4. Ad-p21 (show D4S234E Antibodies) inhibits RNV in OIR. A potential underlying mechanism for this may be that overexpression of p21 (show D4S234E Antibodies) arrests the cell cycle at the G1- to S-phase transition via inhibition of CDK2 activity.

5. CDK2 serves as an important nexus linking primary beta-cell dysfunction to progressive beta-cell mass deterioration in diabetes

6. data indicate that the essential meiotic functions of Cdk2 depend on its kinase activity, without which the generation of haploid cells is disrupted, resulting in sterility of otherwise healthy animals

7. Testosterone is the positive regulator of hepatocyte cell cycle via cyclin E (show CCNE1 Antibodies)/cdk2 promoting hepatocarcinogenesis.

8. This approach allowed us to determine the identity of cyclin E (show CCNE1 Antibodies) protein partners, as well as phosphorylation substrates of cyclins E (cyclin (show PCNA Antibodies) E1and cyclin E2 (show CCNE2 Antibodies))and its associated kinase, Cdk2, in different mouse organs.

9. RingoA (show SPDYA Antibodies) is an important activator of Cdk2 at meiotic telomeres.

10. Foxo3 (show FOXO3 Antibodies) circular RNA retards cell cycle progression via forming ternary complexes with p21 (show D4S234E Antibodies) and CDK2.

Zebrafish Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Antibodies), wee1 (show WEE1 Antibodies), p21 (show CDKN1A Antibodies), PCNA (show PCNA Antibodies) and cdk2, but only weakly influences cyclin B1 (show CCNB1 Antibodies), cyclin B2 (show CCNB2 Antibodies) and cyclin E1 (show CCNE1 Antibodies) expression.

2. PI3-kinase (show PIK3CA Antibodies) and Akt (show AKT1 Antibodies) participate in insulin (show INS Antibodies) stimulation of p34cdc2 (show CDK1 Antibodies) activation in zebrafish oocyte with phosphodiesterase 3 as a potential downstream target.

3. an essential role for UHRF1 (show UHRF1 Antibodies) phosphorylation by cyclin-dependent kinase 2/cyclin A2 (show CCNA2 Antibodies) during early vertebrate development

Cow (Bovine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. cyclin D1 (show CCND1 Antibodies), CDK2 and CDK4 (show CDK4 Antibodies) are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation

Pig (Porcine) Cyclin-Dependent Kinase 2 (CDK2) interaction partners

1. our results indicate that an ATM (show ATM Antibodies)-P53 (show TP53 Antibodies)-P21 (show CDKN1A Antibodies) DNA damage checkpoint is intact in the absence of CDK2; however, CDK2 is important for proper repair of the damaged DNA by either directly or indirectly influencing DNA repair-related gene expression.