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anti-Human Cyclin D1 Antibodies:
anti-Mouse (Murine) Cyclin D1 Antibodies:
anti-Rat (Rattus) Cyclin D1 Antibodies:
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Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN5518654
Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice. in Immunology letters 2013
Show all 40 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN3044355
Ren, Huang, Xu, Yang, Yang, Hu: Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells. in Anti-cancer drugs 2015
Show all 36 Pubmed References
Human Monoclonal Cyclin D1 Primary Antibody for ICC, IHC (fro) - ABIN3043639
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
Show all 36 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN3043483
Wu, Tao, Chen, Xu: RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1. in PLoS ONE 2012
Show all 21 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for IHC, WB - ABIN6712231
Jin, Song, Zhao, Li, Zhao, Liu: Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular carcinoma via Wnt/β-catenin pathway. in Toxicology letters 2014
Show all 17 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for ELISA, ICC - ABIN6261145
Ge, Wang, Ruan, Chen, Liu, Ye: Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells. in OncoTargets and therapy 2016
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Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN498398
Liu, Liu, Lin, Liu, Hou, Hao, Liu, Zhang, Iwamori: Lewis y regulate cell cycle related factors in ovarian carcinoma cell RMG-I in vitro via ERK and Akt signaling pathways. in International journal of molecular sciences 2012
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Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN1881175
Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. in Cancer cell 2010
Show all 6 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for CyTOF, FACS - ABIN4899040
MacLeod et al.: Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced ... in Laboratory investigation; a journal of technical methods and pathology 2013
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Human Polyclonal Cyclin D1 Primary Antibody for IF, IHC - ABIN6714758
Wang, Fei, Lian, Wang, Qiu: Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the phosphatidylinositol 3-kinase/Akt pathway. in Experimental biology and medicine (Maywood, N.J.) 2011
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Overexpression of CCND1 is associated with colorectal cancer.
Cyclin D1 expression is regulated by Hes3 in lung cancer cells.
Study results indicate that CCND1 amplification is associated with worse 15-year survival in ER-positive/lymph node negative/human epidermal growth factor receptor 2 negative, luminal A and luminal B types breast cancer patients. Moreover, luminal A CCND1-amplified tumors display gene expression changes consistent with a more aggressive phenotype.
CCND1 polymorphism rs9344 may not have a role in overall cancer susceptibility in Indian population
a role of cytoplasmic cyclin D1 in the control of MCL cell migration and invasion
Ectopic expression of SNHG1 inhibited miR-326 expression in nucleus pulposus cells and promoted CCND1 expression.
NVP-BEZ235-induced cyclin D1 and cyclin E1 degradation.
CycD1 may have prognostic significance in TNBC.
transcription factor c-Jun bound to the promoter region of human miR-374a and suppressed miR-374a in A549 and pc-9 cells while inducing it in SPCA-1 and H1975 cells. Increased levels of miR-374a appeared to serve a protective role by targeting CCND1 in early-stage non-small-cell lung cancer.
CyclinD1 is frequently expressed in neoplastic Langerhans cells in Langerhans cell histiocytosis. It is an efficient marker to differentiate neoplastic from reactive LC proliferation.
circ_0007766 can up-regulate the expression of Cyclin D1/Cyclin E1/CDK4, which are the key proteins of cell cycle, and thus promote the malignant proliferation of lung adenocarcinoma
P63alpha inhibited cyclin D1 protein expression.
DMSO and the process of freezing did not significantly change the expression of p21 and cyclin D1 genes in human amniotic fluid stem cells
High CCND1 expression is associated with proliferation and invasion of pancreatic cancer.
bergapten significantly increased the subG1 phase ratio to ~9% (P<0.05) in the two cell types. Further investigation demonstrated that bergapten upregulated the expression of cellular tumor antigen p53 (p53) and its downstream proteins cyclindependent kinase inhibitor 1 and cyclindependent kinase inhibitor 1B, whereas, it downregulated the expression of cyclin D1 and CDK4
LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1.
Our results demonstrate that the bacterial effectors that inhibit translation are associated with preventing entry of host cells into a phase associated with restriction of L. pneumophila Furthermore, control of cyclin D1 may be a common strategy used by intracellular pathogens to manipulate the host cell cycle and promote bacterial replication.
set of differentially expressed microRNAs in non-small lung cancer (NSCLC) was identified and the CCND1 gene was determined as the potential prognostic biomarkers for NSCLC.
Gene alterations, such as TP53 mutation, PIK3CA mutation, ERBB2 amplification and CCND1 amplification, and MAPK pathway alteration were associated with pCR in our study.
Cyclin D1 orchestrates expression of a miRNA signature that induces Wnt/beta-catenin signaling, therefore cyclin D1 serves both upstream and downstream of Wnt/beta-catenin signaling.
The results report a novel Sonic Hedgehog (Shh)-initiated circuit that regulates proliferation through coordinated activation of Ccnd1 and forkhead box protein D1 (FOXD1)-mediated suppression of cyclin-dependent kinase inhibitor 1C (Cdkn1c).
The authors' findings establish a firm molecular link of multiaggressiveness among SCP3, NANOG, cyclin D1, and CDK4/6 and identify CDK4/6 inhibitors as actionable drugs for controlling SCP3(high) immune-refractory cancer.
myogenic differentiation is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion.
SALL2 is a negative regulator of cell proliferation, an effect mediated in part by repression of G1-S cyclins' expression.
These results indicate that dysbindin-1A may control the cyclin D1 function spatiotemporally and might contribute to better understanding of the pathophysiology of dysbindin-1-associated disorders.
Elevated expression of miR302-367 in endothelial cells inhibits developmental angiogenesis via CDC42/CCND1 mediated signaling pathways.
autophagic degradation machinery and cyclin D1 linked to liver tumorigenesis
Treatment of mice with established BCL1 leukemia using the scFv-targeted polymer conjugate leads to a markedly prolonged survival time of the experimental animals compared with the treatment using the free drug and the nontargeted polymer-pirarubicin conjugate.
results suggest that DGKdelta controls the down-regulation of cyclin D1 expression by attenuating the PKC signaling pathway for C2C12 myogenic differentiation
the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4.
Since miR-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells
beta-catenin and p65 are activated in separate cellular compartments during liver regeneration, with p65 activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 expression, and subsequent proliferation
Ablation of periostin suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4, Sox2, Klf4, and c-Myc (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 controls osteoclast numbers via a CSF-1-dependent DAG/beta-catenin/cyclinD1 pathway.
Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 regulating cyclin D1 and c-myc transcription in the embryonic eye.
Results suggest that the TCF/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1