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anti-Human Cyclin D1 Antibodies:
anti-Mouse (Murine) Cyclin D1 Antibodies:
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Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN5518654
Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice. in Immunology letters 2013
Show all 40 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN3044355
Ren, Huang, Xu, Yang, Yang, Hu: Isoflavone lupiwighteone induces cytotoxic, apoptotic, and antiangiogenic activities in DU-145 prostate cancer cells. in Anti-cancer drugs 2015
Show all 36 Pubmed References
Human Monoclonal Cyclin D1 Primary Antibody for ICC, IHC (fro) - ABIN3043639
Li, Zhu, Liu, Liu, Wang, Xiong, Shen, Hu, Zheng: ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. in International journal of clinical and experimental pathology 2013
Show all 36 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN3043483
Wu, Tao, Chen, Xu: RhoC regulates the proliferation of gastric cancer cells through interaction with IQGAP1. in PLoS ONE 2012
Show all 21 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for IHC, WB - ABIN6712231
Jin, Song, Zhao, Li, Zhao, Liu: Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular carcinoma via Wnt/β-catenin pathway. in Toxicology letters 2014
Show all 17 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for ELISA, ICC - ABIN6261145
Ge, Wang, Ruan, Chen, Liu, Ye: Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells. in OncoTargets and therapy 2016
Show all 10 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for WB - ABIN1881175
Aggarwal, Vaites, Kim, Mellert, Gurung, Nakagawa, Herlyn, Hua, Rustgi, McMahon, Diehl: Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. in Cancer cell 2010
Show all 6 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for CyTOF, FACS - ABIN4899040
MacLeod et al.: Extracellular calcium-sensing receptor/PTH knockout mice colons have increased Wnt/β-catenin signaling, reduced non-canonical Wnt signaling, and increased susceptibility to azoxymethane-induced ... in Laboratory investigation; a journal of technical methods and pathology 2013
Show all 5 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for IF, IHC - ABIN6714758
Wang, Fei, Lian, Wang, Qiu: Hepatitis B x-interacting protein induces HepG2 cell proliferation through activation of the phosphatidylinositol 3-kinase/Akt pathway. in Experimental biology and medicine (Maywood, N.J.) 2011
Show all 4 Pubmed References
Human Polyclonal Cyclin D1 Primary Antibody for ELISA, WB - ABIN543500
He, Council, Feng, Chignell: UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes. in Cancer research 2008
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Gene alterations, such as TP53 mutation, PIK3CA mutation, ERBB2 amplification and CCND1 amplification, and MAPK pathway alteration were associated with pCR in our study.
Cyclin D1 orchestrates expression of a miRNA signature that induces Wnt/beta-catenin signaling, therefore cyclin D1 serves both upstream and downstream of Wnt/beta-catenin signaling.
these findings indicate that methylationassociated silencing of miR128 promotes the development of esophageal cancer through upregulation of the expression of cyclin D1 and Rb by targeting COX2 in ZD regions with a high incidence of esophageal cancer.
Studied showed Sageretia thea extracts induced cyclin D1 degradation and increased HO-1 expression in a colorectal cancer cell line.
Study demonstrates a measurable nuclear expression of cyclin D1 in post-neoadjuvant residual tumor tissue of hormone receptor-positive breast cancer. Cyclin D1 expression was not prognostic for disease-free survival after neoadjuvant chemotherapy.
Cases of oropharyngeal cancer without human papillomavirus, but cyclin D1 overexpression, were associated with poorer 5-year overall survival.
Results demonstrated that CCND1 mRNA expression levels were upregulated in osteosarcoma (OS) tissues and cells.
Suppression of miR-34c could up-regulate the expressions of its target genes BCL-2 and CCND1 to antagonize the effects of NEAT1 knockdown. Furthermore, overexpressed NEAT1 reduced the sensitivity of cisplatin (DDP) and inhibited DDP-induced apoptosis and cell cycle arrest via miR-34c
knockdown of lncRNA MALAT1 inhibits the proliferation and migration of Bladder Ccancer cells by modulating the miR34a/CCND1 axis.
MiR-142 restricted EC proliferation by targeting CCND1.
Functional analysis showed that the restored miR-623 expression could inhibit the proliferation of GC cells and enhance their chemosensitivity to 5-FU via the cell apoptosis pathway. Cyclin D1 (CCND1) was identified as a direct target gene of miR-623 in GC. The overexpressed CCND1 in GC tissues was negatively correlated with miR-623 level
High CCND1 expression is associated with Osteosarcoma.
The deregulation of miR-17/CCND1 axis during neuroendocrine transdifferentiation of LNCaP prostate cancer cells.
BCL2, CCND1 and COL1A1 may be key novel clinically relevant genes in papillary thyroid carcinoma.
Results provide evidence that CCND1 is transcriptionally regulated by ETV4 facilitating cell cycle progression in pancreatic neoplasm cells.
CCND1 mutations are associated with endometrial adenocarcinoma.
LINC01296 is an oncogenic lncRNA in osteosarcoma. The proliferation, invasion and migration of osteosarcoma cells could be effectively retarded by inhibition of LINC01296. The cancerpromoting effect of LINC01296 on osteosarcoma was determined by cyclin D1.
autophagic degradation machinery and cyclin D1 linked to hepatocellular carcinoma tumorigenesis
FOXD2-AS1 could promote the growth of chondrocytes by targeting miR-206/CCND1 axis.
CCND1 , C-MYC , and FGFR1 amplifications were observed in 34.28%, 28.57%, and 17.14% of the 35 samples (invasive ductal breast carcinoma).
These results indicate that dysbindin-1A may control the cyclin D1 function spatiotemporally and might contribute to better understanding of the pathophysiology of dysbindin-1-associated disorders.
Elevated expression of miR302-367 in endothelial cells inhibits developmental angiogenesis via CDC42/CCND1 mediated signaling pathways.
autophagic degradation machinery and cyclin D1 linked to liver tumorigenesis
Treatment of mice with established BCL1 leukemia using the scFv-targeted polymer conjugate leads to a markedly prolonged survival time of the experimental animals compared with the treatment using the free drug and the nontargeted polymer-pirarubicin conjugate.
results suggest that DGKdelta controls the down-regulation of cyclin D1 expression by attenuating the PKC signaling pathway for C2C12 myogenic differentiation
the focal adhesion component paxillin is a cytoplasmic substrate of Ccnd1.Cdk4.
Since miR-290 cluster miRNAs are the most dominant stem-cell-specific miRNAs, our results revealed an important cause for the absence of Cyclin D1 in mouse embryonic stem cells
beta-catenin and p65 are activated in separate cellular compartments during liver regeneration, with p65 activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 expression, and subsequent proliferation
Ablation of periostin suppresses post-infarction myocardial regeneration by inhibiting the PI3K/GSK3beta/cyclin D1 signalling pathway, indicating that periostin is essential for myocardial regeneration.
Cyclin D1 is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 in hematopoiesis.
NMB or NMBR silencing inhibited M-CSF/c-Fms-mediated downstream signaling pathways like activation of ERK and Akt and induction of D-type cyclins, cyclin D1 and D2.
Histone H2A T120 phosphorylation promotes oncogenic transformation via upregulation of cyclin D1.
our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization.
identify Pax5 and cyclin D1 as Zfp521 target genes, and suggest that excessive B-cell proliferation observed in mice with retroviral insertions near the Zfp521 gene is due to an up-regulation of cyclin D1 in B-cells.
Data show that expression of the Oct-4, Sox2, Klf4, and c-Myc (OSKM) reprogramming factors induces Cyclin D1 expression, and the increased Cyclin D1 expression during reprogramming promotes continuing embryonic fibroblasts (MEFs) proliferation.
study shows that PLCgamma1 controls osteoclast numbers via a CSF-1-dependent DAG/beta-catenin/cyclinD1 pathway.
Regarding extratelomeric activities, our results showed a decrease of 64, 38 and 25% in the transcription of c-Myc, Cyc-D1 and TERT, respectively (p<0.05) after AZT treatment. Furthermore, we found an effect on cell migration, reaching an inhibition of 48% (p<0.05) and a significant passage-dependent increase on cell doubling time during treatment.
Using Ccnd1 knockout mice, the study shows that Ccnd1 expression significantly contributes to tumor incidence in teratoma susceptible mice without being necessary for normal germ cell or testis development.
Ras (G12V)-induced cyclin D1 protein synthesis was markedly suppressed by the knockdown of IL-33.
Novel RNA-binding activity of MYF5 enhances Ccnd1 mRNA translation during myogenesis.
Methylparabens exposure increased malformations, LPO, apoptosis, ccnd1 and myca expressions, and decreased GST activities and NO levels compared with the control group.
while cyclin B1 RNA granules were disassembled in a manner dependent on actin filament depolymerization, certain fractions of mos RNA granules were disassembled independently of actin filaments. These results suggest that cytoplasmic regulation of translationally repressed mRNAs by formation of different RNA granules is a key mechanism for translational control of
show that the knockdown of smc1a in zebrafish impairs neural development, increases apoptosis, and specifically down-regulates Ccnd1 levels
Reduction of cyclin D1 expression compromises zebrafish eye and head development.
Role in cell cycle control is mediated by meis1 regulating cyclin D1 and c-myc transcription in the embryonic eye.
Results suggest that the TCF/LEF signaling pathway participates in the regulation of cyclin D1 induction during the generation of the dorsal nervous system in early frog embryogenesis.
CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells.
cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 kinase) pathway.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
B-cell CLL/lymphoma 1
, B-cell lymphoma 1 protein
, BCL-1 oncogene
, G1/S-specific cyclin-D1
, PRAD1 oncogene
, G1/S-specific cyclin-D1 b
, cyclin D1 b
, parathyroid adenomatosis 1
, G1/S-specific cyclin-D1 a
, cyclin D1 a (PRAD1: parathyroid adenomatosis 1)
, cyclin D1 (PRAD1: parathyroid adenomatosis 1)
, cyclin D1