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anti-Human NCF1 Antibodies:
anti-Mouse (Murine) NCF1 Antibodies:
anti-Rat (Rattus) NCF1 Antibodies:
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Human Polyclonal NCF1 Primary Antibody for WB - ABIN2801889
Volpp, Nauseef, Donelson, Moser, Clark: Cloning of the cDNA and functional expression of the 47-kilodalton cytosolic component of human neutrophil respiratory burst oxidase. in Proceedings of the National Academy of Sciences of the United States of America 1989
Show all 4 Pubmed References
Mouse (Murine) Polyclonal NCF1 Primary Antibody for IHC, ELISA - ABIN1531722
Lee, Ko, Jeong, Park, Kim: β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia. in Journal of neuroinflammation 2015
Show all 2 Pubmed References
Mouse (Murine) Polyclonal NCF1 Primary Antibody for ELISA, IF - ABIN1586076
Kim, Ryu, Kang: Status epilepticus induces vasogenic edema via tumor necrosis factor-α/ endothelin-1-mediated two different pathways. in PLoS ONE 2014
Human Polyclonal NCF1 Primary Antibody for IHC, ELISA - ABIN1531718
Kröller-Schön, Steven, Kossmann, Scholz, Daub, Oelze, Xia, Hausding, Mikhed, Zinßius, Mader, Stamm, Treiber, Scharffetter-Kochanek, Li, Schulz, Wenzel, Münzel, Daiber: Molecular mechanisms of the crosstalk between mitochondria and NADPH oxidase through reactive oxygen species - studies in white blood cells and in animal models. in Antioxidants & redox signaling 2013
Show all 2 Pubmed References
Human Polyclonal NCF1 Primary Antibody for IF (p), IHC (p) - ABIN1385194
Chen, Ye, Zhang, Tang, Li, Lu, Wu, Yu, Kou: Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils. in International journal of molecular sciences 2016
Human Polyclonal NCF1 Primary Antibody for IF (p), IHC (p) - ABIN1387732
Almajdoob, Hossain, Anand-Srivastava: Resveratrol attenuates hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats: Role of ROS and ROS-mediated cell signaling. in Vascular pharmacology 2018
Human Polyclonal NCF1 Primary Antibody for ELISA, IHC (p) - ABIN256632
Davidson-Moncada, Lopez-Lluch, Segal, Dekker: Involvement of protein kinase D in Fc gamma-receptor activation of the NADPH oxidase in neutrophils. in The Biochemical journal 2002
Mouse (Murine) Polyclonal NCF1 Primary Antibody for ELISA, WB - ABIN4338257
Roos, Kuhns, Maddalena, Bustamante, Kannengiesser, de Boer, van Leeuwen, Köker, Wolach, Roesler, Malech, Holland, Gallin, Stasia: Hematologically important mutations: the autosomal recessive forms of chronic granulomatous disease (second update). in Blood cells, molecules & diseases 2010
p47phox S-glutathionylation plays an essential key role in the sustained ROS (show ROS1 Antibodies) generation by human neutrophils.
patients with hereditary p47phox deficiency show reduced platelet activation suggesting a role for this Nox cytosolic subunit in platelet activation.
Decreased and increased copy numbers of NCF1 predispose to and protect against SLE.
Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck (show HCK Antibodies)-dependent activation of PKCdelta (show PKCd Antibodies), which stimulates PKCgamma (show PRKCG Antibodies), resulting in translocation of phosphorylated p47(phox).
There was an increased frequency of the NCF1-339 T allele in patients with systemic lupus erythematosus. The NCF1-339 T allele reduced extracellular ROS (show ROS1 Antibodies) production in neutrophils and led to an increase expression of type 1 interferon (show IFNA Antibodies)-regulated genes.
Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Antibodies) subunits p22(phox (show CYBA Antibodies)), p47(phox), and p67(phox (show NCF2 Antibodies)) was increased in obese relative to lean subjects, where p22(phox (show CYBA Antibodies)) and p67(phox (show NCF2 Antibodies)) expression was attenuated by exercise training in obese subjects.
A novel role for Spns2 (show SPNS2 Antibodies) and S1P1 (show S1PR1 Antibodies)&2 in the activation of p47(phox) and production of reactive oxygen species involved in hyperoxia-mediated lung injury.
Study provides evidence for a novel PKC-zeta (show PRKCZ Antibodies) to p47phox interaction that is required for cell transformation from blebbishields and ROS (show ROS1 Antibodies) production in cancer cells.
Overexpression of p47phox is associated with increased migration/metastasis rate in melanoma.
A rare mutation in NCF1 encoding p47phox of the leukocyte NADPH oxidase (show NOX1 Antibodies) causes lack of superoxide generation, leads to chronic granulomatous disease and was recently (1200-2300 years ago) introduced into the Kavkazi Jewish population
Myricitrin attenuated the generation of intracellular ROS (show ROS1 Antibodies) by inhibiting the assembly of components of the gp91(phox (show CYBB Antibodies)) and p47(phox). Suppression of ROS (show ROS1 Antibodies) generation using NAC (show NLRP1 Antibodies) or apocynin or by silencing gp91(phox (show CYBB Antibodies)) and p47(phox) all demonstrated that decreasing the level of ROS (show ROS1 Antibodies) inhibited the LPS (show TLR4 Antibodies)-induced inflammatory response.
Results show that Ncf1 is not needed during juvenility to protect from autoimmune arthritis later on, but conditional Ncf1 suppresses arthritis even if activated after the disease priming. The study presents in vivo evidence that Ncf1/reactive oxygen species-regulated mechanisms are different in priming than in the effector phase.
we used the Ang II (show AGT Antibodies) infused hph-1 (show EGLN2 Antibodies) mice to examine the roles of NOX isoforms in the development of AAA (show AAAS Antibodies). We generated double mutants of hph-1 (show EGLN2 Antibodies)-NOX1 (show NOX1 Antibodies), hph-1 (show EGLN2 Antibodies)-NOX2 (show CYBB Antibodies), hph-1 (show EGLN2 Antibodies)-p47phox, and hph-1 (show EGLN2 Antibodies)-NOX4 (show NOX4 Antibodies)
Mice bearing point mutation in the Ncf1-gene develop fewer osteoclasts after ovariectomy (ovx) than wild-type mice. However, irrespective of genotype, bone mineral density decreases after ovx, indicating that a compensatory mechanism retains bone degradation after ovx.
The authors demonstrated a significant role of the host NADPH oxidase (show NOX1 Antibodies) in promoting chronic inflammatory pathology in the oviduct following chlamydial infection.
data partly explains the discrepancy of the phenotypes reported earlier utilizing the Ncf1m1J mice or Ncf1 knockout mice.
Data (including data from studies in transgenic mice) suggest that ability to generate Ncf1-derived superoxide, specifically in CD4 (show CD4 Antibodies)-positive T-lymphocytes, is key for development of autoimmune responses in type 1 diabetes.
The Park7 (show PARK7 Antibodies) binds to p47(phox), a subunit of the NADPH oxidase (show NOX1 Antibodies), to promote NADPH oxidase (show NOX1 Antibodies)-dependent production of ROS (show ROS1 Antibodies).
p47(phox)-dependent NADPH oxidases are a major glomerular source of reactive oxygen species, contributing to kidney injury
p47phox mRNA expression was increased in diet-induced obese (DIO) mice. p47phox suppresses collateral vessel growth after femoral artery ligation in DIO mice.
Differential Roles of Protein Complexes NOX1-NOXO1 and NOX2-p47phox in Mediating Endothelial Redox Responses to Oscillatory and Unidirectional Laminar Shear Stress.
two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8)encoding two putative truncated proteins (239AA and 283AA). Two splice variants were up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows.
A p47(phox) and Src kinase (show CSK Antibodies) activation of peroxide production by Nox2 (show CYBB Antibodies) appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C (show PKC Antibodies).
Angiotensin II inhibits the Na+/K+ pump via PKC (show PKC Antibodies)-dependent activation of NADPH oxidase (show NOX1 Antibodies) subunits.
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in this gene have been associated with chronic granulomatous disease.
47 kDa autosomal chronic granulomatous disease protein
, 47 kDa neutrophil oxidase factor
, NADPH oxidase organizer 2
, SH3 and PX domain-containing protein 1A
, neutrophil NADPH oxidase factor 1
, neutrophil cytosol factor 1
, neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1)
, nox organizer 2
, nox-organizing protein 2
, NADPH oxidase subunit (47 kD)
, NADPH oxidase subunit (47kDa)
, phagocyte oxidase 47 kDa
, neutrophil cytosolic factor 1 (47kDa, chronic granulomatous disease, autosomal 1)
, NADPH oxidase p47-phox
, predicted neutrophil cytosolic factor 1