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Human PIK3CG Protein expressed in HEK-293 Cells - ABIN2728968
Hashimoto, Tanaka, Takeda, Ito, Nagano et al.: Cilostazol Induces PGI2 Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLC? and to Activate p44/42 MAPK in Human Aortic Endothelial ... in PLoS ONE 2015
PI3Kdelta and PI3Kgamma inhibition with IPI-145 has anti-proliferative activity in primary AML (show RUNX1 Proteins) cells by inhibiting the activity of AKT (show AKT1 Proteins) and MAPK (show MAPK1 Proteins)
we propose that the PKA-Smurf1 (show SMURF1 Proteins)-PIPKIgamma pathway has an important role in pulmonary tumorigenesis and imposes substantial clinical impact on development of novel diagnostic markers and therapeutic targets for lung cancer treatment.
A positive correlation may exist between PIK3CG single nucleotide polymorphisms and patients with poor responsiveness to clopidogrel.
PI3K (show PIK3CA Proteins), independently of protein kinase B (show AKT1 Proteins), has a role in parasite-induced netosis. One of the main isoforms involved is PI3Kgamma which works in a reactive-oxygen-species-dependent way.
Diminished expression of p110gamma in pulmonary vascular endothelial cells of patients with acute respiratory distress syndrome suggests that impaired p110gamma-FoxM1 vascular repair signaling is a critical factor in persistent leaky lung microvessels in ARDS.
Findings suggest the pathophysiological role of phosphoinositide 3-kinase gamma (PI3Kgamma) in atherogenesis.
Our findings suggest that p84 (show PPP1R12C Proteins) binding to p110gamma may represent a novel negative feedback signal that terminates PI3Kgamma activity.
findings suggest that miR (show MLXIP Proteins)-502 functions as a tumor suppressor in HCC (show FAM126A Proteins) via inhibition of PI3KCG, supporting its utility as a promising therapeutic gene target for this tumor type
PI3Kgamma plays an important role in the development of eosinophilic inflammation a
PI3Kgamma-induced VEGF (show VEGFA Proteins) expression was reduced when the human tocopherol-associated protein (show SEC14L2 Proteins) 1 (hTAP1/SEC14L2 (show SEC14L2 Proteins)) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer.
In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.
CSF2 (show CSF2 Proteins) stimulates proliferation of trophectoderm cells by activation of the PI3K-and ERK1/2 MAPK (show MAPK1 Proteins)-dependent MTOR (show FRAP1 Proteins) signal transduction cascades.
A linear relationship of EGF/EGFR (show EGFR Proteins), PI3-kinase (show PIK3CA Proteins), MAPK (show MAPK1 Proteins) and geminal vesicle breakdown, presents a relatively definitive mechanism of EGF (show EGF Proteins)-induced meiotic resumption of porcine oocyte.
PI3Kg ablation protects mice from obesity, inflammation, and insulin (show INS Proteins) resistance caused by high-fat diet feeding.
The results showed that PI3K-gamma is likely a crucial element in sepsis-induced myocardial dysfunction (SIMD) by regulating the PI3K/Akt (show AKT1 Proteins) pathway, and become a new marker of myocardial injury. Inhibition of PI3K-gamma might be a potential therapeutic target in SIMD.
Phosphatidylinositol-3-kinases (PI3K) gamma and delta are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kgamma or PI3Kdelta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals alternative transplant survival outcomes post CTLA4 (show CTLA4 Proteins)-Ig treatment.
PI3Kgamma kinase activity-independent control of cAMP phosphodiesterase as a crucial mediator of microglial cAMP regulation, MMP-9 (show MMP9 Proteins) expression, and phagocytic activity following focal brain ischemia/recirculation.
We report here that PI3Kgamma regulates macrophage transcriptional programming, leading to T-cell suppression, desmoplasia, and metastasis in pancreas adenocarcinoma.
a STOP mutation in the GM-CSFRalpha (show CSF2RA Proteins) chain, leading to a complete and specific deficiency in GM-CSF (show CSF2 Proteins) signaling, is reported.
increased levels of eosinophils and IgE in p110gamma/delta-/- mice do not abolish the protective effect of p110gamma/delta-deficiency against OVAlbumin (show OVA Proteins)-induced allergic airway inflammation.
The Effector PI3Kgamma Is Required for Toll (show TLR4 Proteins)-like Receptors-induced Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) Signaling and Regulation of Cytokine Responses.
macrophage PI 3 (show PI3 Proteins)-kinase gamma controls a critical switch between immune stimulation and suppression during inflammation and cancer; therapeutic targeting of intracellular signalling pathways that regulate the switch between macrophage polarization states can control immune suppression in cancer and other disorders
Accumulation of PtdIns(3,4,5)P3, but not PtdIns(3,4)P2,in neutrophils were dependent on PI3Kgamma activity.
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
, phosphoinositide-3-kinase, catalytic, gamma polypeptide
, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like
, 1-phosphatidylinositol 3-kinase
, PI3-kinase subunit gamma
, phosphatidylinositol 3 kinase gamma, p110 gamma
, phosphatidylinositol 3-kinase catalytic 110-kD gamma
, phosphatidylinositol 3-kinase, catalytic, gamma polypeptide
, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma
, phosphoinositide-3-kinase gamma catalytic subunit
, ptdIns-3-kinase subunit gamma
, ptdIns-3-kinase subunit p110-gamma
, serine/threonine protein kinase PIK3CG
, catalytic subunit of G-beta-gamma-activated
, phosphoinositide-3-kinase catalytic gamma polypeptide