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AIF (show AIFM1 Proteins)-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls
Upregulated expression of AIFM3 is associated with cholangiocarcinoma.
The expression of apoptosis-inducing factor (show AIFM1 Proteins) was identified in pineal gland and thymus, but it did not change with age.
AIFM3 is a direct target of miR (show MLXIP Proteins)-210 in human hepatoma cells.
AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase (show TXNRD1 Proteins) domain (Pyr_redox). AIFL shares 35% homology with AIF (show AIFM1 Proteins), mainly in the Pyr_redox domain.
AIF (show AIFM1 Proteins) maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function.
H. pylori triggers apoptosis in AGS (show JAG1 Proteins) cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c (show CYCS Proteins) and AIF (show AIFM1 Proteins) from mitochondria, and activation of subsequent downstream apoptotic events
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity).
apoptosis-inducing factor, mitochondrion-associated, 3
, neurula-specific ferredoxin reductase-like protein
, novel protein similar to vertebrate apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3)
, apoptosis-inducing factor 3-like
, apoptosis-inducing factor 3
, apoptosis-inducing factor like
, apoptosis-inducing factor-like protein
, apoptosis-inducing factor, mitochondrion-associated 3