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AIF-deficient mice display similar rates of H2O2 release and protein carbonyl modifications in brain mitochondria compared to WT controls
AIFM3 was significantly more expressed in breast cancer tissues than in normal tissues. There was a significant association of AIFM3 expression with tumor size, lymph node metastasis, molecular typing and TNM staging. Lymph node metastasis and TNM stage were independent factors of AIFM3 expression. High AIFM3 expression was related to a shorter OS and DFS.
Upregulated expression of AIFM3 is associated with cholangiocarcinoma.
The expression of apoptosis-inducing factor was identified in pineal gland and thymus, but it did not change with age.
AIFM3 is a direct target of miR-210 in human hepatoma cells.
AIFL has 598 amino acids, with a characteristic Rieske domain and a pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). AIFL shares 35% homology with AIF, mainly in the Pyr_redox domain.
AIF maintains the transformed state of colon cancer cells through its NADH oxidase activity, by mechanisms that involve complex I function.
H. pylori triggers apoptosis in AGS cells via interaction with death receptors in the plasma membrane, leading to the cleavage of procaspase-8, release of cytochrome c and AIF from mitochondria, and activation of subsequent downstream apoptotic events
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity).
apoptosis-inducing factor, mitochondrion-associated, 3
, neurula-specific ferredoxin reductase-like protein
, novel protein similar to vertebrate apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3)
, apoptosis-inducing factor 3-like
, apoptosis-inducing factor 3
, apoptosis-inducing factor like
, apoptosis-inducing factor-like protein
, apoptosis-inducing factor, mitochondrion-associated 3