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Human CYR61 Protein expressed in Wheat germ - ABIN1351026
Jeansonne, Pacifici, Lassak, Reiss, Russo, Zabaleta, Peruzzi: Differential Effects of MicroRNAs on Glioblastoma Growth and Migration. in Genes 2014
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refine the leukocyte recruitment cascade model by introducing endothelium-bound CCN1 as an inflammation mediator and by demonstrating a role for platelets and patrolling Ly6C(low) monocytes in acute vascular inflammation.
This study is the first to describe how CCN1 (show CCNA2 Proteins) promotes VEGF (show VEGFA Proteins) expression in osteoblasts and increased endothelial progenitor cells angiogenesis in rheumatoid arthritis disease.
Data show that cysteine rich protein 61 protein (CCN1) critically mediates doxorubicin (DOX)-induced cardiotoxicity.
Our results not only reveal a novel mechanism illustrating the role of Cyr61 in epidermis pathogenesis but also suggest that therapies targeting Cyr61 may represent a novel strategy in the treatment of psoriasis vulgaris.
The LPA1 (show LPAR1 Proteins)-CCN1 (show CCNA2 Proteins) axis may be the central control for SMC (show DYM Proteins) migration.
these data suggest that the WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway enhances pancreatic cancer development and malignancy in part via up-regulation of CYR61.
Lysophosphatidic acid induced time-dependent phosphorylation of serum response factor and CRE-binding protein in in smooth muscle cells, inducing transcription of CCN1.
Data show that Cysteine-rich 61 (CYR61) acts as a tumor-promoting gene in pancreatic neuroendocrine tumors.
CCN1 is an important regulator of chondrocyte maturation during cartilage development and homeostasis.
CCN1 exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway.
our study suggests that suppression of Cyr61 in cancer stem cell-like cells in PDAC may inhibit tumor cell metastasis after resection of the primary tumor.
CYR61 promotes breast cancer lung metastasis by facilitating tumor cell extravasation and protecting from anoikis during initial seeding to the lung.
Knockdown of CYR61 in gastric cancer AGS (show JAG1 Proteins) cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis.
Two interacting partners of urokinase-type plasminogen activator (uPA) receptor (show PLAUR Proteins), the cysteine-rich angiogenic inducer 61 (Cyr61) and the Y-box-binding protein 1 (YB-1 (show YBX1 Proteins)) were identified and their differential expression demonstrated in the triple-negative breast cancer (TNBC) cells as well as in tumors.
collagen II-activated phosphorylated-DDR2 (show DDR2 Proteins) induces CYR61 through activation of transcription factor activator protein 1 (AP-1 (show FOSB Proteins)). The elevated CYR61, in turn, accelerates MMP1 (show MMP1 Proteins) production via ETS1 (ETS (show ETS1 Proteins) proto-oncogene (show RAB1A Proteins) 1).
Cyr61 stimulated MMP-3 (show MMP3 Proteins) production in fibroblast-like synoviocytes of rheumatoid arthritis patients.
Low CCN1 expression is associated with esophageal cancer.
this study found that expression of Cyr61 was higher in the ectopic endometrium than in the eutopic endometrium and that Cyr61 expression in the endometrium was correlated with age, number of natural labors, blood loss, uterine volume, adenomyosis type, and concurrent endometriosis
The role of CYR61 in aromatase (show CYP19A1 Proteins) inhibitors resistance in estrogen receptor (show ESR1 Proteins) positive breast cancer patients
The increased expression of CYR61 in the Day 4 corpus lutum (CL) and its transient increase by prostaglandin F2alpha in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL.
Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.
Mechanical regulation of the Cyr61 gene in smooth muscle cells
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
cysteine-rich, angiogenic inducer, 61
, SMT3 suppressor of mif two 3 homolog 3
, small ubiquitin-related modifier 3
, protein CYR61-like
, CCN family member 1
, IGF-binding protein 10
, cysteine-rich angiogenic inducer 61
, insulin-like growth factor binding protein 10
, insulin-like growth factor-binding protein 10
, intermediate early
, protein CYR61
, cysteine-rich heparin-binding protein 61
, cysteine-rich, anigogenic inducer, 61
, cysteine rich protein 61
, secreted cysteine-rich protein cyr61