CYR61 Protein
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- Target See all CYR61 Proteins
- CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Sequence
- MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPVRFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGETF SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD
- Characteristics
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Purified recombinant Human CYR61 protein
Expression System: E.coli
Bioactivity: Determined by the dose-dependent stimulation of the proliferation of Mouse 3T3 cells. The expected ED50 for this effect is 2.0-3.0 µg/mL. - Purity
- > 95 % pure
- Endotoxin Level
- < 0.1 ng per µg (1 EU/µg).
- Top Product
- Discover our top product CYR61 Protein
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Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 1-381) protein (GST tag)
CYR61 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (His tag)CYR61 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 293-381) protein (GST tag)CYR61 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (GST tag)CYR61 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-381) protein (His tag)Crystallography grade CYR61 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Cysteine-Rich, Angiogenic Inducer, 61 (CYR61) (AA 25-379) protein (His tag)Crystallography grade CYR61 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- Supplied as a lyophilized powder.
- Handling Advice
- Avoid repeated freeze/thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.
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- Target
- CYR61 (Cysteine-Rich, Angiogenic Inducer, 61 (CYR61))
- Alternative Name
- CYR61 (CYR61 Products)
- Background
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CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules), the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Alternative Names: CYR61, CYR6-1 protein, CYR-61 protein, CYR 61, CYR 61 protein, CYR-61, CCN1 protein, GIGI protein protein - Pathways
- Positive Regulation of Endopeptidase Activity, Growth Factor Binding
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