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The information represented in the study confirmed previous reports. And it may assist to discover and design new backbones as potential XO inhibitors based on natural products.
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The role of xanthine oxidoreductase and uric acid in metabolic syndrome.
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Data found that gastric cancer patients adhering to the SNP rs207454 CC genotype had favorable clinical outcome compared with those carrying the AA/AC genotypes, suggesting that the CC allele was a protective allele in the prognosis of gastric cancer by effecting XDH mRNA expression level.
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this study shows that XOR is required for genotoxic stress-induced NKG2D ligand expression and gemcitabine-mediated antitumor activity
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Molecular docking simulations clarified that purpurogallins have stronger affinities for XO than corresponding pyrogallols. These results revealed that the potent XO inhibitory activity seemingly observed in pyrogallol is actually derived from its chemical conversion, under alkaline conditions, into purpurogallin.
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data suggest that Alcohol use disorders augment pulmonary and systemic XOR activity that may contribute to ROS and uric acid generation, promoting inflammation.
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XO is a useful marker to assess oxidative stress in polycystic ovary syndrome patients
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xanthine dehydrogensase gene expression and uric acid production is altered in asthma and in human airway epithelial cells
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Among cardiac patients, left ventricular hypertrophy, low LVEF, and increased BNP were significantly associated with plasma XOR activity independent of various confounding factors.
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we demonstrated that BP rise over time and/or the risk of hypertension are associated with three SNP in the XOR gene: rs2043013, rs11904439, and rs148756340.
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Hypoxanthine-xanthine oxidase axis is not involved in the initial phase of clinical transplantation-related ischemia-reperfusion injury in kidney allograft recipients.
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Serum XOD activity was higher in type 2 DM patients than in control subjects and was higher in diabetic patients with diabetic peripheral neuropathy than in those without neuropathy.
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XOR activity is correlated with insulin resistance, BMI, and subclinical inflammation.
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Study showed that DKK3 promotes cell survival during oxidative stress by suppressing XDH expression, thereby abrogating excess reactive oxygen species accumulation and subsequent apoptosis.
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Results show XOR strictly modulated at the transcriptional and post-translational levels, and its expression and activity are highly variable in cancer and negatively associated with high malignity grade and a worse prognosis. [review]
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XDH and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.
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beneficial effects observed with XO inhibitors on cardiovascular disease in chronic kidney disease may also be due to the reduction of oxidative stress
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Thyroid stimulating hormone levels are increase in gout patients treated with inhibitors of xanthine oxidoreductase.
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The XDH gene polymorphisms rs1042039, rs1054889, and rs2073316 were shown to be associated with hypertension in a rural Chinese population.
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genetic association studies in population in Mexico: Data suggest that SNPs in XO (1936A>G, 2107A>G) are not associated with development of typical adverse reactions to methotrexate in pediatric patients with ALL (acute lymphoblastic leukemia).