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Browse our anti-PHPT1 (PHPT1) Antibodies

Full name:: anti-phosphohistidine Phosphatase 1 Antibodies (PHPT1)

On www.antibodies-online.com are 128 phosphohistidine Phosphatase 1 (PHPT1) Antibodies from 22 different suppliers available. Additionally we are shipping PHPT1 Proteins (20) and PHPT1 Kits (17) and many more products for this protein. A total of 169 PHPT1 products are currently listed.

Synonyms:: 1700008C22Rik, bA216L13.10, CGI-202, HSPC141, MGC131298, Php14, RP11-216L13.10, wu:fb50e08, zgc:101086

list all antibodies	Gene Name	GeneID	UniProt
	PHPT1	29085	Q9NRX4
	PHPT1	75454	Q9DAK9
	PHPT1	296571
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Most Popular Reactivities for anti-PHPT1 (PHPT1) Antibodies

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anti-Human PHPT1 Antibodies:

anti-Mouse (Murine) PHPT1 Antibodies:

anti-Rat (Rattus) PHPT1 Antibodies:

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Relevant Pathways for anti-PHPT1 Antibodies

Positive Regulation of Peptide Hormone Secretion

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Top referenced anti-PHPT1 Antibodies

Human Polyclonal PHPT1 Primary Antibody for IHC (p), ELISA - ABIN543523 : Mehrle, Rosenfelder, Schupp, del Val, Arlt, Hahne, Bechtel, Simpson, Hofmann, Hide, Glatting, Huber, Pepperkok, Poustka, Wiemann: The LIFEdb database in 2006. in Nucleic acids research 2005 (PubMed)
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Human Polyclonal PHPT1 Primary Antibody for IHC (p), ELISA - ABIN543522 : Ma, Kanders, Sundh, Geng, Ek, Zetterqvist, Li: Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity. in Biochemical and biophysical research communications 2005 (PubMed)
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Human Polyclonal PHPT1 Primary Antibody for EIA, IHC (p) - ABIN5552099 : Shen, Yang, Liu, Tian: Nuclear expression and clinical significance of phosphohistidine phosphatase 1 in clear-cell renal cell carcinoma. in The Journal of international medical research 2016 (PubMed)
Human Polyclonal PHPT1 Primary Antibody for ICC, IF - ABIN4345386 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

More Antibodies against PHPT1 Interaction Partners

Human phosphohistidine Phosphatase 1 (PHPT1) interaction partners

In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM
High PHPT1 expression is associated with cancer.
H2O2 exposure induces selective oxidation of hPHPT1 at Met95, a residue within the substrate binding region. Molecular dynamics simulations suggest that if Met95 oxidation alters hPHPT1 activity, then it will do so by altering the stability of an intermediate state. Mass spectrometry showed that H2O2-induced oxidation does not impact hPHPT1 function negatively.
PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma tissue samples.
PHPT1 can dephosphorylate phospholysine in chemically phosphorylated histone H1 and polylysine
The specific degradation of the PHPT1 splice variant indicates that the quality control and the self-guarding of the cellular system works at two levels, first at the RNA level and proteasome level.
the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 in inside/out patch experiments.
Overexpression of PHP by the use of a plasmid vector, pIRES2-AcGFP1-PHP, induced apoptosis in HUVEC
Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer.
these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin secretion
These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement.
Northern blot analysis indicated that the human phosphohistidine phosphatase mRNA was present preferentially in heart and skeletal muscle.
In the present work, we have searched for potential active site residues in the human phosphohistidine phosphatase by point mutations of conserved histidine and arginine residues to alanine.
Overexpression of PHP results in increased dephosphorylation with concomitant inactivation of ACL, thus finally leading to cell damage.
PHPT-1 functions to negatively regulate CD4 T cells
Solution structure and catalytic mechanism of human protein histidine phosphatase 1.
results suggest that an increased activity of protein histidine phosphatase (PHP) impairs neuron cellular function whereas downregulation of PHP does not

Mouse (Murine) phosphohistidine Phosphatase 1 (PHPT1) interaction partners

PHPT-1(-/-) mice exhibited neonatal hyperinsulinemic hypoglycemia due to impaired trafficking of KATP channels to the plasma membrane in pancreatic beta-cells in response to low glucose and leptin and resembled patients with congenital hyperinsulinism (CHI).

PHPT1 Antigen Profile

Antigen Summary

PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002

Alternative names and synonyms associated with PHPT1

phosphohistidine phosphatase 1 (LOC424401) antibody
phosphohistidine phosphatase 1 (phpt1) antibody
phosphohistidine phosphatase 1 (PHPT1) antibody
phosphohistidine phosphatase 1 L homeolog (phpt1.L) antibody
14 kDa phosphohistidine phosphatase-like (LOC100511240) antibody
phosphohistidine phosphatase 1 (Phpt1) antibody

1700008C22Rik antibody
bA216L13.10 antibody
CGI-202 antibody
HSPC141 antibody
MGC131298 antibody
Php14 antibody
RP11-216L13.10 antibody
wu:fb50e08 antibody
zgc:101086 antibody

Protein level used designations for PHPT1

phosphohistidine phosphatase 1 , 14 kDa phosphohistidine phosphatase , 1700008C22Rik , phosphohistidine phosphatase 14kDa , protein janus-A homolog , sex-regulated protein janus-a , 14kDa phosphohistidine phosphatase

GENE ID	SPECIES
424401	Gallus gallus
445172	Danio rerio
491245	Canis lupus familiaris
734838	Xenopus laevis
770750	Gallus gallus
100174576	Pongo abelii
100511240	Sus scrofa
29085	Homo sapiens
75454	Mus musculus
296571	Rattus norvegicus
618691	Bos taurus

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Show all anti-phosphohistidine Phosphatase 1 (PHPT1) Antibodies with Pubmed References

Human phosphohistidine Phosphatase 1 (PHPT1) interaction partners

Mouse (Murine) phosphohistidine Phosphatase 1 (PHPT1) interaction partners

Antigen Summary

Alternative names and synonyms associated with PHPT1

Protein level used designations for PHPT1