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anti-Human PHPT1 Antibodies:
anti-Mouse (Murine) PHPT1 Antibodies:
anti-Rat (Rattus) PHPT1 Antibodies:
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Human Polyclonal PHPT1 Primary Antibody for ICC, IF - ABIN4345386
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
In the process of assay optimization, we discovered that PHPT1 is sensitive to a reducing environment and inhibited by transition-metal ions, with one apparent Cu(II) binding site with IC50 value of 500 +/- 20 muM and two apparent Zn(II) binding sites with IC50 values of 25 +/- 1 and 490 +/- 20 muM
High PHPT1 expression is associated with cancer.
PHPT1 was expressed in the epithelium of proximal tubuli and nuclei of clear-cell renal cell carcinoma (show MOK Antibodies) tissue samples.
PHPT1 can dephosphorylate phospholysine in chemically phosphorylated histone H1 (show H1F0 Antibodies) and polylysine
The specific degradation of the PHPT1 splice variant indicates that the quality control and the self-guarding of the cellular system works at two levels, first at the RNA level and proteasome level.
the histidine phosphatase, protein histidine phosphatase 1, inhibits NDPK-B-activated TRPV5 (show TRPV5 Antibodies) in inside/out patch experiments.
Overexpression of PHP (show ASAH1 Antibodies) by the use of a plasmid vector, pIRES2-AcGFP1-PHP (show ASAH1 Antibodies), induced apoptosis in HUVEC
Significantly higher expression levels of PHPT1 protein were found in lung cancer samples than in normal tissues adjacent to lung cancer.
these data implicate regulatory roles for PHPT1 in a G protein-sensitive step involved in nutrient-induced insulin (show INS Antibodies) secretion
These results demonstrate for the first time that PHP14 may be functionally important in lung cancer cell migration and the invasion of lung cancer cells, mediated partly through modulation of actin cytoskeleton rearrangement.
PHPT-1(-/-) mice exhibited neonatal hyperinsulinemic hypoglycemia due to impaired trafficking of KATP channels to the plasma membrane in pancreatic beta-cells in response to low glucose and leptin (show LEP Antibodies) and resembled patients with congenital hyperinsulinism (CHI).
PHPT1 is an EDTA-insensitive phosphohistidine phosphatase that catalyzes the dephosphorylation of phosphopeptide I (Ek et al., 2002
phosphohistidine phosphatase 1
, 14 kDa phosphohistidine phosphatase
, phosphohistidine phosphatase 14kDa
, protein janus-A homolog
, sex-regulated protein janus-a
, 14kDa phosphohistidine phosphatase