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anti-Human INO80 Antibodies:
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Cow (Bovine) Polyclonal INO80 Primary Antibody for ELISA - ABIN4226781
Yao, Song, Jin, Cai, Takahashi, Swanson, Washburn, Florens, Conaway, Cohen, Conaway: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. in Molecular cell 2008
INO80-silencing MSC (show MSC Antibodies) cultured in osteogenic condition expressed lower mRNA levels of osteoblast-specific genes, including Runx2 (show RUNX2 Antibodies), Osx (show MID1 Antibodies), Col1alpha1 and OCN. INO80 can interact with Wdr5 (show WDR5 Antibodies) in MSC (show MSC Antibodies) and positively regulates the canonical Wnt (show WNT2 Antibodies) signaling transduction.
Instead nucleosome sliding requires cooperativity between two INO80 complexes that monitor DNA length simultaneously on either side of the nucleosome during sliding. The C-terminal domain of the human Ino80 subunit (Ino80CTD) binds cooperatively to DNA and dimerisation of these domains provides crosstalk between complexes.
Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression.
By demonstrating a key role for SUMOylation in regulating the INO80 chromatin remodeling complex, this work illustrates the power of bioinformatics analysis of large data sets in predicting novel biological phenomena.
Our work defines SETD2 as a tumor suppressor gene in Hepatosplenic T-cell lymphoma (HSTL)and implicates genes including INO80 and PIK3CD in the disease
our study defines a critical role of INO80 in promoting oncogenic transcription and NSCLC tumorigenesis, and reveals a potential treatment strategy for inhibiting the cancer transcription network by targeting the INO80 chromatin remodeling complex.
Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 (show YY1 Antibodies) in this process have been described.
The inositol hexaphosphate binding site is located within the C-terminal region of the Ino80 subunit.
the existence of both INO80 and YY1 (show YY1 Antibodies) is required for recruiting the INO80/YY1 (show YY1 Antibodies) complex to BCCIP (show BCCIP Antibodies) promoter region. Our findings strongly indicate that BCCIP (show BCCIP Antibodies) is a potential target gene of the INO80/YY1 (show YY1 Antibodies) complex.
The expression of Ino80, the SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) ATPase (show DNAH8 Antibodies), is elevated in melanoma cells and patient melanomas compared with normal melanocytes and benign nevi.
Data show that deletion of the Ino80 in vascular endothelial cells prevents ventricular compaction in the developing heart.
Mot1 (show BTAF1 Antibodies), Ino80 chromatin remodeling complex (Ino80C (show INO80C Antibodies)), and NC2 (show GTF2H5 Antibodies) co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination
Ino80 represses Bmp4 (show BMP4 Antibodies) expression during embryonic stem cell differentiation.
INO80 is stabilized and targeted to replication forks by BAP1 (show BAP1 Antibodies) during normal DNA synthesis but downregulated in BAP1 (show BAP1 Antibodies) defective cancer cells
data reveal an essential role for INO80 in the expression of the pluripotency network and illustrate the coordination among chromatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the pluripotent state.
The mIno80 chromatin remodeling complex plays important roles in telomere replication, HDR (show GATA3 Antibodies)-mediated repair of dysfunctional telomeres, and maintenance of genome stability.
observations reveal a link between YY1 (show YY1 Antibodies) and INO80 and roles for both in homologous recombination-based repair, providing new insight into mechanisms that control the cellular response to genotoxic stress
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.
DNA helicase INO80
, INO80 complex subunit A
, INO80 homolog
, homolog of yeast INO80
, putative DNA helicase INO80 complex homolog 1
, INO80 complex homolog 1
, yeast INO80-like protein