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anti-Human INO80 Antibodies:
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Cow (Bovine) Polyclonal INO80 Primary Antibody for ELISA - ABIN4226781
Yao, Song, Jin, Cai, Takahashi, Swanson, Washburn, Florens, Conaway, Cohen, Conaway: Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. in Molecular cell 2008
Data report a single-molecule level assay for INO80, based on the relative movement of FRET labels on the nucleosome. Results found that while binding wild-type and all tailless nucleosomes with equal affinity, the bound state of INO80 in the presence of ADP is homogenous for wild-type nucleosomes and heterogeneous for all tailless nucleosomes.
human INO80 chromatin remodeling complex is more compositionally heterogenous at its genomic targets than anticipated.
structure of the human INO80 chromatin remodeller with a bound nucleosome, which reveals that INO80 interacts with nucleosomes in a previously undescribed manner
INO80-silencing MSC cultured in osteogenic condition expressed lower mRNA levels of osteoblast-specific genes, including Runx2, Osx, Col1alpha1 and OCN. INO80 can interact with Wdr5 in MSC and positively regulates the canonical Wnt signaling transduction.
Instead nucleosome sliding requires cooperativity between two INO80 complexes that monitor DNA length simultaneously on either side of the nucleosome during sliding. The C-terminal domain of the human Ino80 subunit (Ino80CTD) binds cooperatively to DNA and dimerisation of these domains provides crosstalk between complexes.
Ino80 was upregulated in cervical cancer and promoted cell proliferation and tumorigenesis by binding to the Nanog transcription start site and enhancing its expression.
By demonstrating a key role for SUMOylation in regulating the INO80 chromatin remodeling complex, this work illustrates the power of bioinformatics analysis of large data sets in predicting novel biological phenomena.
Our work defines SETD2 as a tumor suppressor gene in Hepatosplenic T-cell lymphoma (HSTL)and implicates genes including INO80 and PIK3CD in the disease
our study defines a critical role of INO80 in promoting oncogenic transcription and NSCLC tumorigenesis, and reveals a potential treatment strategy for inhibiting the cancer transcription network by targeting the INO80 chromatin remodeling complex.
Interactions of the chromatin remodeling protein INO80 with DNA, and the role of YY1 in this process have been described.
The inositol hexaphosphate binding site is located within the C-terminal region of the Ino80 subunit.
the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex.
The expression of Ino80, the SWI/SNF ATPase, is elevated in melanoma cells and patient melanomas compared with normal melanocytes and benign nevi.
Overexpression of miRNA-148a and knockdown of INO80 acted synergistically to decrease the expression of stem cell marker genes as well as to attenuate stem cell-specific properties including the ability to form tumors.
INO80 complex negatively regulates p21 expression in a p53-mediated mechanism and is implicated in cell cycle phase G2/M arrest and abnormal chromosome stability.
INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Mutations in INO80D is associated with translocation renal cell carcinoma.
The data indicate that under conditions of replication stress INO80 protects stalled forks from collapsing and allows their subsequent restart.
human Inositol auxotrophy 80 (Ino80) SNF2 ATPase is subject to regulation at multiple levels in the INO80 chromatin-remodeling complex.
These results suggest that the human INO80 complex, like the yeast complex, was involved in the DNA damage tolerance pathway and that phosphorylation of human INO80 was involved in the DNA damage tolerance pathway.
Data show that deletion of the Ino80 in vascular endothelial cells prevents ventricular compaction in the developing heart.
Mot1, Ino80 chromatin remodeling complex (Ino80C), and NC2 co-localize on chromatin and coordinately suppress pervasive transcription in murine embryonic stem cells.
The loss of INO80 resulted in an arrest during meiosis associated with a failure to repair DNA damage during meiotic recombination
Ino80 represses Bmp4 expression during embryonic stem cell differentiation.
data reveal an essential role for INO80 in the expression of the pluripotency network and illustrate the coordination among chromatin remodeler, transcription factor, and histone-modifying enzyme in the regulation of the pluripotent state.
The mIno80 chromatin remodeling complex plays important roles in telomere replication, HDR-mediated repair of dysfunctional telomeres, and maintenance of genome stability.
observations reveal a link between YY1 and INO80 and roles for both in homologous recombination-based repair, providing new insight into mechanisms that control the cellular response to genotoxic stress
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.
DNA helicase INO80
, INO80 complex subunit A
, INO80 homolog
, homolog of yeast INO80
, putative DNA helicase INO80 complex homolog 1
, INO80 complex homolog 1
, yeast INO80-like protein