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CTNNBL1 regulates multiple splicing events and gene expression in ovarian cancer cells
Tthis study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group.
The results show that CTNNBL1 enhances the association of CWC15 (show CWC15 Proteins) and CDC5L (show CDC5L Proteins), both core Prp19 (show PRPF19 Proteins) complex proteins and identify an overlap in the region of CDC5L (show CDC5L Proteins) that binds either CTNNBL1 or CWC15 (show CWC15 Proteins) suggesting the two proteins might exchange places in the complex.
Variants in the gene CTNNBL1 (encoding catenin-beta-like 1, located on chromosome 20 q11.23-q12) have been found to be associated with verbal episodic memory performance.
The crystal structure of CTNNBL1 shows that the protein coalphansists mainly of alpha-helices and forms an armadillo (show PKP1 Proteins) (ARM) repeat. structure
Results indicate CTNNBL1 as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas.
CTNNBL1 crystal structure provides critical insights into the molecular interactions between CTNNBL1 and its protein partners.
From this gene expression data and fMRI experiments suggests a role for the beta-catenin-like protein 1 in human episodic memory.
There are abnormal expression of beta-catenin and activation of Wnt signaling pathway in human esophageal carcinoma cell line Eca-109.
There was a significantly positive correlation between LMP1 (show PDLIM7 Proteins) expression and abnormal expression of beta-catenin (show CTNNB1 Proteins) in nasopharyngeal carcinoma tissue.
CTNNBL1 plays no essential role in cycling cells but does fulfill an evolutionarily conserved function in helping cells to undergo efficient exit from quiescence following activation.
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L (show CDC5L Proteins) and Prp31 (show PRPF31 Proteins)
Normal levels of immunoglobulin class switch recombination (CSR) factors are found in DTNNBL1-deficient cells, indicating that CTNNBL1 is dispensable for CSR.
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity.
catenin, beta like 1
, beta-catenin-like protein 1
, beta catenin-like 1
, platelet-derived growth factor receptor, alpha polypeptide
, beta-catenin-like protein 1-like
, nuclear associated protein
, testis development protein NYD-SP19
, nuclear protein NAP
, nuclear-associated protein