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CTNNBL1 regulates multiple splicing events and gene expression in ovarian cancer cells
Tthis study identified WNT5B and CTNNBL1 for peak bone mineral density and body composition in males from the Han Chinese ethnic group.
The results show that CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex.
Variants in the gene CTNNBL1 (encoding catenin-beta-like 1, located on chromosome 20 q11.23-q12) have been found to be associated with verbal episodic memory performance.
The crystal structure of CTNNBL1 shows that the protein coalphansists mainly of alpha-helices and forms an armadillo (ARM) repeat. structure
Results indicate CTNNBL1 as a unique selective nuclear localization signals (NLSs)-binding protein with striking differences from karyopherin-alphas.
CTNNBL1 crystal structure provides critical insights into the molecular interactions between CTNNBL1 and its protein partners.
From this gene expression data and fMRI experiments suggests a role for the beta-catenin-like protein 1 in human episodic memory.
There are abnormal expression of beta-catenin and activation of Wnt signaling pathway in human esophageal carcinoma cell line Eca-109.
There was a significantly positive correlation between LMP1 expression and abnormal expression of beta-catenin in nasopharyngeal carcinoma tissue.
CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
Study suggests a novel mechanism for the development of obesity, where CTNNBL1 may play an important role.
The results, therefore, identify residues in AID involved in its in vivo targeting and suggest they might act through interaction with CTNNBL1, giving possible insight into the linkage between AID recruitment and target-gene transcription.
We detected no confirmation of the recent association of variants in CTNNBL1 with obesity in a population of Central European ancestry
CTNNBL1 variants associated with body weight and height, and confer the risk of developing obesity
The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity.
catenin, beta like 1
, beta-catenin-like protein 1
, beta catenin-like 1
, platelet-derived growth factor receptor, alpha polypeptide
, beta-catenin-like protein 1-like
, nuclear associated protein
, testis development protein NYD-SP19
, nuclear protein NAP
, nuclear-associated protein