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Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.
VPREB1 focal deletions are common in B-ALL and occur independent of V(D)J light chain recombination. Focal deletions of VPREB1 correlate with decreased expression levels and high-risk patients with focal deletions tend to have poorer overall survival
The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls.
The 5' region of the VpreB gene contains a promoter which displays higher relative activity in preB cells compared with cells at other stages or from other lineages.
Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells.
Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice.
VpreB probes the fitness of newly generated VH domains of IgH chains for later pairing with IgL chains, and its non-Ig part fixes the preBCRs on the surface.
Mice triply deficient for VpreB1 show B cell developmental defects but functional allelic exclusion of the IgH locus.
To identify the sequences that regulate lambda5 and VpreB1 expression during B cell development, the DNaseI hypersensitive sites in the lambda5-VpreB1 functional domain were mapped.
Multiple receptor-dependent mechanisms operating at all stages of B cell development limit the contribution of B cells with Dmu heavy chain alleles to the repertoire.
The epigenetic profile of immunoglobulin light chain (IgL) genes is strongly influenced by pre-B cell receptor signaling and by the differentiative stage of the progenitor lymphocytes.
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation.
pre-B lymphocyte 1
, pre-B lymphocyte gene 1
, CD179 antigen-like family member A
, immunoglobulin iota chain
, v(pre)B protein
, Immunoglobulin lambda Vpreb1 chain